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Systemic meglumine antimoniate-induced severe dilated cardiomyopathy.
Dermatol Ther
December 2022
Dermatology Department, Farhat Hached University Hospital, University of Sousse, Tunisia.
Meglumine antimoniate-induced DRESS: original case with a positive skin test.
Acta Parasitol
December 2018
Department of Pharmacology, University of Medicine, Avenue Avicenne 5019 Monastir, Tunisia.
Article Synopsis
- A 64-year-old woman treated with the drug meglumine antimoniate developed symptoms like fever, skin rash, and muscle pain 20 days into treatment, which were linked to drug-induced DRESS syndrome.
- Blood tests indicated problems like eosinophilia and liver damage, but her condition improved after stopping the medication.
- The case is notable as it not only documents a rare instance of DRESS caused by this drug but also confirms the diagnosis with positive skin tests, marking the first of its kind reported in the literature.
Genistein and Ascorbic Acid Reduce Oxidative Stress-Derived DNA Damage Induced by the Antileishmanial Meglumine Antimoniate.
Antimicrob Agents Chemother
September 2018
Laboratório de Genética e Biologia Molecular, Departamento de Biologia, Universidade Federal do Maranhão, Cidade Universitária Dom Delgado, São Luís, Maranhão, Brazil
Meglumine antimoniate (Glucantime) is a pentavalent antimonial used to treat leishmaniasis, despite its acknowledged toxic effects, such as its ability to cause oxidative damage to lipids and proteins. Recently, our group demonstrated that meglumine antimoniate causes oxidative stress-derived DNA damage. Knowing that antioxidants modulate reactive oxygen species, we evaluated the capacity of genistein and ascorbic acid for preventing genotoxicity caused by meglumine antimoniate.
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