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Label-Free and Sequence-Independent Isothermal Amplification Strategy for the Simultaneous Detection of Genomic 5-Methylcytosine and 5-Hydroxymethylcytosine.
Anal Chem
January 2025
School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are crucial epigenetic modifications in eukaryotic genomic DNA that regulate gene expression and are associated with the occurrence of various cancers. Here, we combined bisulfite conversion with 4-acetamido-2,2,6,6-tetramethyl-1-oxopiperridinium tetrafluoroborate (ACTBF, TCI) oxidation to develop a label-free and sequence-independent isothermal amplification (BTIA) assay for a genome-wide 5mC and 5hmC analysis. The BTIA strategy can distinguish 5mC and 5hmC signatures from other bases with high sensitivity and good specificity, avoiding sophisticated chemical modifications and expensive protein labeling.
View Article and Find Full Text PDFThe social self in the developing brain.
Neurosci Biobehav Rev
January 2025
Department of Psychology, University of Virginia, USA. Electronic address:
The notion that the self is fundamentally social in nature and develops through social interactions has a long tradition in philosophy, sociology, and psychology. However, to date, the early development of the social self and its brain bases in infancy has received relatively little attention. This presents a review and synthesis of existing neuroimaging research, showing that infants recruit brain systems, involved in self-processing and social cognition in adults, when responding to self-relevant cues during social interactions.
View Article and Find Full Text PDFHarnessing Genetic Resistance in Maize and Integrated Rust Management Strategies to Combat Southern Corn Rust.
J Fungi (Basel)
January 2025
Plant Protection Institute, Hebei Academy of Agriculture and Forestry Sciences, Key Laboratory of Integrated Pest Management on Crops in Northern Region of North China, Ministry of Agriculture and Rural Affairs, China, IPM Innovation Center of Hebei Province, International Science and Technology Joint Research Center on IPM of Hebei Province, Baoding 071000, China.
Southern corn rust (SCR) caused by Underw. has recently emerged as a focal point of study because of its extensive distribution, significant damage, and high prevalence in maize growing areas such as the United States, Canada, and China. is an obligate biotrophic fungal pathogen that cannot be cultured in vitro or genetically modified, thus complicating the study of the molecular bases of its pathogenicity.
View Article and Find Full Text PDFMonitoring Radical Intermediates in Photoactivated Palladium-Catalyzed Coupling of Aryl Halides to Arenes by an Aryl Radical Assay.
ACS Catal
January 2025
Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
An aryl radical assay is used to provide information about the formation of aryl radicals from aryl halides in coupling reactions to arenes in the presence of palladium sources and under LED irradiation (λ = 456 nm). The assay uses 2-halo--xylenes as substrates. Aryl radical formation is indicated both by a defined product composition and by signature deuterium isotope effects.
View Article and Find Full Text PDFInvestigating the Spatio-Temporal Signatures of Language Control-Related Brain Synchronization Processes.
Hum Brain Mapp
February 2025
Université libre de Bruxelles (ULB), UNI - ULB Neuroscience Institute, Laboratoire de Neuroanatomie et Neuroimagerie translationnelles (LN2T), Brussels, Belgium.
Language control processes allow for the flexible manipulation and access to context-appropriate verbal representations. Functional magnetic resonance imaging (fMRI) studies have localized the brain regions involved in language control processes usually by comparing high vs. low lexical-semantic control conditions during verbal tasks.
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