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Diagnostic Laboratory Stewardship in a Growing Integrated Delivery Network.
J Appl Lab Med
January 2025
Department of Pathology & Laboratory Services, Banner University Medical Center-Tucson, Tucson, AZ, United States.
Background: Many organizations institute laboratory diagnostic stewardship (DS) programs to improve the utilization of laboratory resources.
Methods: In this paper, we describe the road to implementing laboratory DS in a large, not-for-profit integrated delivery network located in the western United States.
Results: Program structure, projects, challenges, and future opportunities are discussed, providing tactics and opportunities that facilities can employ to maximize their initial foray into the DS landscape.
Safety of Low-Dose Quetiapine for Insomnia in Older Adults.
Drugs Aging
January 2025
Pharmacy Outcomes Research Group, Kaiser Permanente, 12254 Bellflower Blvd, Downey, CA, 90242, USA.
Background And Objective: Quetiapine is a Food and Drug Administration (FDA) approved second-generation antipsychotic. It is also commonly used at low dose for its sedative properties to treat insomnia in the older population. Quetiapine at standard doses has been associated with increased risk of cerebrovascular events, cognitive decline, and mortality in patients with dementia, especially within older adults.
View Article and Find Full Text PDFThe global impact of the COVID-19 pandemic on delays and disruptions in cancer care services: a systematic review and meta-analysis.
Nat Cancer
January 2025
Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.
The coronavirus disease 2019 pandemic substantially impacted the delivery of cancer services and programs. Here we reviewed and synthesized the global scale and impact of pandemic-related delays and disruptions on cancer services, including diagnosis, diagnostic procedures, screening, treatment and supportive and palliative care. Based on data from 245 articles in 46 countries, we observed declines in the number of cancer screening participation (39.
View Article and Find Full Text PDFMachine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology.
Nat Commun
January 2025
NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & University College London Institute of Ophthalmology, London, UK.
Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived a continuous, measured metric, the retinal pigment score (RPS), that quantifies the degree of pigmentation from a colour fundus photograph of the eye. RPS was validated using two large epidemiological studies with demographic and genetic data (UK Biobank and EPIC-Norfolk Study) and reproduced in a Tanzanian, an Australian, and a Chinese dataset.
View Article and Find Full Text PDFEvaluating the 3-month post-intervention impact of a supportive text message program on mental health outcomes during the 2023 wildfires in Alberta and Nova Scotia, Canada.
Front Public Health
January 2025
Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- Individuals exposed to wildfires can develop mental health issues, but supportive text interventions may help mitigate these effects over time.
- The study focused on evaluating a text message support service (Text4Hope) over three months in Alberta and Nova Scotia after the 2023 wildfires, involving participants who completed surveys to assess their mental health before and after the intervention.
- Results indicated significant improvements in wellbeing and reductions in symptoms of depression, anxiety, and PTSD, suggesting the effectiveness of text message support in promoting mental health resilience after disasters.
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