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Impact of Genomic Classifiers on Risk Stratification and Treatment Intensity in Patients With Localized Prostate Cancer : A Systematic Review.
Ann Intern Med
January 2025
Durham VA Health Care System, Durham; and Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina (K.M.G.).
Background: Tissue-based genomic classifiers (GCs) have been developed to improve prostate cancer (PCa) risk assessment and treatment recommendations.
Purpose: To summarize the impact of the Decipher, Oncotype DX Genomic Prostate Score (GPS), and Prolaris GCs on risk stratification and patient-clinician decisions on treatment choice among patients with localized PCa considering first-line treatment.
Data Sources: MEDLINE, EMBASE, and Web of Science published from January 2010 to August 2024.
A deep learning tissue classifier based on differential Co-expression genes predicts the pregnancy outcomes of cattle.
Biol Reprod
January 2025
Inner Mongolia SK·Xing Animal Breeding and Breeding Biotechnology Research Institute Co., Ltd, Hohhot 011517, China.
Economic losses in cattle farms are frequently associated with failed pregnancies. Some studies found that the transcriptomic profiles of blood and endometrial tissues in cattle with varying pregnancy outcomes display discrepancies even before artificial insemination (AI) or embryo transfer (ET). In the study, 330 samples from seven distinct sources and two tissue types were integrated and divided into two groups based on the ability to establish and maintain pregnancy after AI or ET: P (pregnant) and NP (nonpregnant).
View Article and Find Full Text PDFInvestigation of the effect of thyroid collar, radiation safety glasses and lead apron on radiation dose in cone beam computed tomography.
Dentomaxillofac Radiol
January 2025
Assist. Prof. Dr, Selcuk University Faculty of Medicine, Department of Radiation Oncology, Konya, 42130, Turkiye.
Objectives: Due to the increasing use of cone-beam computed tomography (CBCT) in dentistry and considering the effects of radiation on radiosensitive organs, the aim of this study was to investigate the effect of shielding on absorbed dose of eyes, thyroid and breasts in scans conducted with different parameters using two different fields of view (FOV).
Methods: Dose measurements were calculated on a tissue-equivalent female phantom by repeating each scanning parameter three times and placing at least two thermoluminescent dosimeters (TLD) on each organ, with the averages then taken. The same CBCT scans were performed in two different FOV with shielding including thyroid collar, radiation safety glasses and lead apron and without shielding.
Oral health and rheumatoid arthritis: a case control study.
Cent Eur J Public Health
December 2024
Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic.
Objectives: Patients suffering from rheumatoid arthritis (RA) are repeatedly affected by oral diseases or problems, including dental caries and periodontal diseases (PDs). Periodontitis and rheumatoid arthritis are chronic inflammatory destructive diseases that share many similarities. The objective of this study was to assess oral health status including examination of hard dental tissues and periodontium in patients with rheumatoid arthritis and compare the results with healthy controls.
View Article and Find Full Text PDFPrevalence of overweight and obesity in 6-15-year-old boys and girls before the COVID-19 pandemic: results from anthropological research 2001-2019 in the Czech Republic.
Cent Eur J Public Health
December 2024
Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic.
Objective: Childhood overweight and obesity has been a major global problem for a long time, with a steadily increasing prevalence of obesity and a growing number of cases of serious health complications associated with childhood obesity. The main objective of the study is to assess the prevalence of overweight and obesity in boys and girls before the COVID-19 pandemic in the Czech Republic.
Methods: Body height, weight, BMI, and body composition (fat free mass, skeletal muscle mass, body fat, visceral fat area) were assessed in a cohort of 4,475 subjects (2,180 boys and 2,295 girls) aged 6-15 years.
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