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Menopause has a beneficial influence on the evolution of prolactinomas. A study of 99 patients.
J Clin Endocrinol Metab
March 2025
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Context: Menopause is thought to have beneficial effects in women with prolactinoma, potentially offering a higher chance for successful dopamine agonist (DA) withdrawal. However, strong evidence supporting this remains limited.
Objective: To assess the impact of menopause on prolactinoma evolution and recurrence after DA withdrawal.
Guidance for shared decision-making regarding orchiectomy in individuals with differences of sex development due to 17-β-hydroxysteroid dehydrogenase type 3 deficiency.
Front Pediatr
February 2025
University of Cincinnati College of Medicine, Cincinnati, OH, United States.
17β-hydroxysteroid dehydrogenase type 3 deficiency is a 46,XY difference of sex development (DSD) that may present in childhood with inguinal testes or at puberty following virilization. We present four individuals, assigned female at birth, to highlight complexities and considerations surrounding orchiectomy. We reviewed the literature and created a "FACT sheet" to guide shared decision-making for patients, parents, and providers.
View Article and Find Full Text PDFMenopause part I: Vasomotor symptoms (I).
Taiwan J Obstet Gynecol
March 2025
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Female Cancer Foundation, Taipei, Taiwan; Department of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan. Electronic address:
Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production of estrogen) without another pathological or physiological cause becomes one of the most health issues in the world. Vasomotor symptoms (VMS) is a hallmark of menopause, occurring in up to 80 % of women experiencing and persisting for over seven years with significant negative impacts on physical, psychological, social, and overall wellbeing. Conventionally, menopause hormone therapy (MHT) is considered the most effective therapeutic opinion for many years based on the fact as "deficiency of estrogen"; however, the ratio of benefits and risk is highly debated and always in concern.
View Article and Find Full Text PDFSex differences in immunity are well-documented, though mechanisms underpinning these differences remain ill-defined. Here, in a human-only ex vivo study, we demonstrate that postpubertal cisgender females have higher levels of CD19+CD27+IgD- class-switched memory B cells compared with age-matched cisgender males. This increase is only observed after puberty and before menopause, suggesting a strong influence for sex hormones.
View Article and Find Full Text PDFAromatase enzyme deficiency in an adult male patient and the effects of estrogen replacement therapy: a rare cause of tall stature.
Hormones (Athens)
March 2025
Department of Endocrinology, and Metabolism, Marmara University School of Medicine, Istanbul, Turkey.
Aromatase enzyme deficiency (AED) is a rare autosomal recessive disorder caused by mutations in the CYP19A1 gene. This disorder causes an inability to convert androgens into estrogens, resulting in excess androgens and estrogen deficiency. AED is typically diagnosed in female infants, but diagnosis in men is often delayed until adulthood due to late-onset skeletal and metabolic issues.
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