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Inosine exerts dopaminergic neuroprotective effects via mitigation of NLRP3 inflammasome activation.
Neuropharmacology
March 2025
College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea. Electronic address:
Neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Transformation of pro-interleukin (IL)-1β into a mature IL-1β via active inflammasome may be related to the progression of PD. Therefore, the modification of inflammasome activity may be a potential therapeutic strategy for PD.
View Article and Find Full Text PDFAcute CCl-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics - protective role of succinate.
J Bioenerg Biomembr
December 2024
Laboratory of Experimental Biophysics, Centre for Advanced Technologies, Tashkent, Uzbekistan.
The main therapeutic strategy for the treatment of patients with toxic liver failure is the elimination of the toxic agent in combination with the targeted mitigation of pathological processes that have been initiated due to the toxicant. In the current research we evaluated the strategy of metabolic supplementation to improve mitochondrial bioenergetics during acute liver intoxication. In our study, we have shown that acute CCl-induced intoxication negatively affects Complex I (in the presence of glutamate-malate as energy substrates) based respiration, generation of mitochondrial membrane potential (ΔΨ), mitochondrial NAD(P)H pool and NADH redox index, mitochondrial calcium retention capacity (CRC) and structure and functions of the liver.
View Article and Find Full Text PDFThe effect of intraoperative inosine infusion on transplant outcomes in deceased-donor kidney transplant recipients.
Ren Fail
December 2024
Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Objectives: It is unknown when inosine was first employed as a renoprotective agent in the context of kidney transplantation procedures. However, there is no clinical evidence to support a protective role of inosine. The aim of this study was to investigate the effect of inosine on graft recovery.
View Article and Find Full Text PDFThe antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins.
J Biol Chem
December 2024
Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. Electronic address:
The human gastrointestinal tract is a competitive environment inhabited by dense polymicrobial communities. Bacteroides, a genus of Gram-negative anaerobes, are prominent members of this ecological niche. Bacteroides spp.
View Article and Find Full Text PDF[Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy].
Zh Nevrol Psikhiatr Im S S Korsakova
October 2024
Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan.
Objective: Evaluation of the effectiveness of Cytoflavin as a neuroprotective therapy for neurological complications in premature newborns with hypoxic-ischemic encephalopathy.
Material And Methods: 56 premature newborns with low body weight were examined. Newborn children, depending on the therapy, were divided into 2 groups: Group I - 32 premature newborns with hypoxic-ischemic encephalopathy; received basic therapy and Cytoflavin; Group II - 24 premature newborns with hypoxic-ischemic encephalopathy; received only basic therapy.
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