AI Article Synopsis

  • The study investigated the link between the outflow facility of aqueous humor and the size measurements of Schlemm's canal (SC) in both healthy and glaucomatous eyes.
  • It found a significant correlation, with glaucomatous eyes exhibiting notably smaller SC cross-sectional areas, perimeters, and inner wall lengths compared to normal eyes.
  • The reduced dimensions of SC in glaucoma patients could explain about 41-55% of the decreased outflow facility observed in their eyes.

Article Abstract

The purpose of the study was to examine the correlation between outflow facility and morphometric measurements of Schlemm's canal (SC) in normal and glaucomatous human eyes. Outflow facility was measured in ten normal and five glaucomatous (POAG) human eyes prior to perfusion-fixation at a pressure of 15 mmHg. Two separate sections per quadrant (eight sections per eye) were analysed using a morphometric analysis system. SC cross sectional area, perimeter, and inner wall length were measured. Inner wall endothelial nuclei were counted. When pooled data were examined, a statistically significant correlation was found between facility and SC area (P < or = 0.01). Most importantly, POAG eyes had a significantly smaller SC cross-sectional area, SC perimeter and SC inner wall length compared to normal eyes. If examined as a reduction in SC filtering area, this decrease in SC inner wall length alone could account for approximately 41-55% of the difference in outflow facility observed between normal and POAG eyes. The dimensions of Schlemm's canal in glaucomatous human eyes were significantly smaller than those in normal eyes. This reduction in SC dimensions may account for approximately half of the decrease in outflow facility observed in POAG eyes.

Download full-text PDF

Source
http://dx.doi.org/10.1006/exer.1996.0012DOI Listing

Publication Analysis

Top Keywords

outflow facility
20
schlemm's canal
16
inner wall
16
human eyes
12
wall length
12
poag eyes
12
normal glaucomatous
8
glaucomatous human
8
eyes
8
area perimeter
8

Similar Publications

Intraocular pressure (IOP) elevation is the primary risk factor and currently the main treatable factor for progression of glaucomatous optic neuropathy. In addition to direct clinical and living animal in vivo studies, ex vivo perfusion of anterior segments and whole eyes is a key technique for studying conventional outflow function as it is responsible for IOP regulation. We present well-tested experimental details, protocols, considerations, advantages, and limitations of several ex vivo model systems for studying IOP regulation.

View Article and Find Full Text PDF

This study analyzes hospital bed capacity and resource allocation using inflow and outflow indices to identify disparities in bed utilization. The COVID-19 pandemic highlighted the need for effective healthcare management, particularly in the allocation of specialized beds such as those in intensive care units (ICU). Despite a high bed-to-population ratio, South Korea faces regional disparities in bed distribution, especially in Seoul, which accounts for 12.

View Article and Find Full Text PDF

The importance of boundary evolution for solar-wind modelling.

Sci Rep

November 2024

Solar Physics Laboratory, NASA/GSFC, Mail Code 671, Greenbelt, MD, 20771, USA.

The solar wind is a continual outflow of plasma and magnetic field from the Sun's upper atmosphere-the corona-that expands to fills the solar system. Variability in the near-Earth solar-wind conditions can produce adverse space weather that impacts ground- and space-based technologies. Consequently, numerical fluid models of the solar wind are used to forecast conditions a few days ahead.

View Article and Find Full Text PDF

Roles of Prostaglandins and Hydrogen Sulfide in an Outflow Model of the Porcine Ocular Anterior Segment Ex Vivo.

Pharmaceuticals (Basel)

September 2024

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.

Background: Hydrogen sulfide (HS)-releasing compounds can reduce intraocular pressure in normotensive rabbits by increasing aqueous humor (AH) outflow through the trabecular meshwork. In the present study, we investigated the contribution of endogenous HS and the role of intramurally generated prostaglandins in the observed increase in AH outflow facility in an ex vivo porcine ocular anterior segment model.

Material And Methods: Porcine ocular anterior segment explants were perfused with Dulbecco's Modified Eagle's Medium maintained at 37 °C and gassed with 5% CO and 95% air under an elevated pressure of 15 mmHg for four hours.

View Article and Find Full Text PDF

Mouse Model of Glucocorticoid-Induced Glaucoma.

Methods Mol Biol

October 2024

Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA.

Article Synopsis
  • Extended glucocorticoid treatment can cause ocular hypertension and lead to iatrogenic open-angle glaucoma, resembling primary open-angle glaucoma (POAG).
  • Researchers have shown that weekly injections of dexamethasone-21-acetate in mice result in significant intraocular pressure (IOP) increase, retinal ganglion cell loss, and optic nerve damage.
  • The mouse model exhibits key features of POAG and can be used to explore how glaucoma affects the trabecular meshwork and retinal ganglion cell axons, as well as to test new treatment methods.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!