A one-year (1993) survey of the distribution of pathogens causing respiratory and urinary infections and their antimicrobial susceptibility was performed. The most common bacteria isolated from the lower respiratory tract of patients in a district general hospital were Pseudomonas aeruginosa (35.9%) and Staphylococcus aureus (21.4%). About half of the Pseudomonas strains revealed a resistance to imipenem and gentamicin, whereas almost all Staphylococcus strains were resistant to penicillin G. The most common isolates from urine of in and out-patients were Escherichia coli (32.3% and 39.8%) and Enterococcus faecalis (16.6% and 14.2%). Escherichia coli strains were largely susceptible to almost all chemoantibiotics tested, whereas Enterococcus faecalis demonstrated a high resistance pattern. Pseudomonas aeruginosa isolated from urine were more sensitive to chemoantibiotics than respiratory strains and the susceptibility of Staphylococcus aureus isolated from hospitalized or out-patients was different. A periodic monitoring system devised to give information about the circulation of bacteria and the chemoantibiotic resistance in a local context would be useful to assess the local trends and select drugs for therapy.
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Diabetol Int
January 2025
Department of Endocrinology and Diabetes, NTT Medical Center Tokyo, 141-86255-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo Japan.
A 73-year-old Japanese woman was admitted to our hospital with anorexia, weight loss, and fever. A few weeks prior to admission, she became aware of anorexia. She was leukopenic, complement-depleted, and positive for antinuclear antibodies and anti-double stranded DNA antibodies.
View Article and Find Full Text PDFBMC Res Notes
January 2025
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 37000, Pakistan.
Objective: The dispensing of non-prescription antibiotics is a worldwide concern, and antibiotics should only be dispensed with a legitimate prescription.
Methodology: A cross-sectional study was conducted using the simulated client methodology, with data collected, recorded, and analyzed using SPSS.
Results: The simulated client visited 210 pharmacies, of which 70 dispensed antibiotics without a prescription.
BMC Genomics
January 2025
Centre for Environmental Health, Hasselt University, Hasselt, Belgium.
Background: Telomere length is an important indicator of biological age and a complex multi-factor trait. To date, the telomere interactome for comprehending the high-dimensional biological aspects linked to telomere regulation during childhood remains unexplored. Here we describe the multi-omics signatures associated with childhood telomere length.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
January 2025
Dept of Respiratory Medicine, Harefield Hospital, Hill End Rd, UB9 6JH, London, UK. Electronic address:
Objectives: Antibacterial-resistant gram-negative hospital-acquired infections result in significant morbidity and mortality. In clinical trials, ceftolozane/tazobactam (C/T) has been effective against these infections; however, real-world findings are limited.
Methods: SPECTRA was a global, retrospective, observational inpatient study of adults treated with C/T for ≥48 hours, conducted between 2016 and 2020.
Viruses
December 2024
Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL 32608, USA.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for causing the Coronavirus disease 2019 (COVID-19) outbreak. While mutations cause the emergence of new variants, the ancestral SARS-CoV-2 strain is unique among other strains. Various clinical parameters, the activity of cathepsin proteases, and the concentration of various proteins were measured in urine samples from COVID-19-negative participants and COVID-19-positive participants.
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