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"3D channel maze" to control drug release from multiple unit tablets.
J Control Release
December 2024
Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:
Diffusion is defined as general mechanism for drug release from advanced delivery systems, yet dynamic structure of dosage form intrinsically plays an unknown role. The synchrotron radiation X-ray micro-computed tomography (SR-μCT) three-dimensional (3D) imaging and in-depth analysis of 3D structures were applied to readily differentiate materials and accurately capture internal structure changes of multiple unit pellet system (MUPS) and the constituent pellets, visualizing internal 3D structure of a MUPS of theophylline tablets for their 3 levels hierarchy structures: pellets with rapid drug release characteristics, a protective cushion layer and a matrix layer. Drug release pathways were extracted from SR-μCT images and a 3D maze network was constructed using pore network analysis to quantify the internal structural evolution during drug release.
View Article and Find Full Text PDFExploration of a Novel Terpolymer Nanoparticle System for the Prevention of Alcohol-Induced Dose Dumping.
Mol Pharm
December 2024
Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Alcohol-induced dose dumping (AIDD) remains a serious challenge in the controlled delivery of high potency drugs, such as opioids, which requires extensive investigation and innovative solutions. Current technologies rely on ethanol-insoluble excipients, such as guar gum and sodium alginate, to counteract the increased solubility of hydrophobic polymeric excipients in ethanol. However, these excipients pose several shortcomings, such as high viscosity of coating dispersion, high solution temperature, rapid gelation, and heterogeneity of resulted film.
View Article and Find Full Text PDFMetabolic function and quality contribution of tea-derived microbes, and their safety risk in dark tea manufacture.
Food Chem
February 2025
School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address:
Microbial fermentation, especially the microbes involved, plays a crucial role in the quality formation of dark tea. Over the last decade, numerous microbes have been isolated from dark tea and in turn, applied to dark tea manufacture through pure-strain, mixed-strain, and enhanced fermentation. This article systematically summarizes the specific metabolic function and quality contribution of tea-derived microbes, with special attention paid to their safety risk.
View Article and Find Full Text PDFThe Key Role of Wettability and Boundary Layer in Dissolution Rate Test.
Pharmaceutics
October 2024
Department of Engineering and Architecture, University of Trieste, Via Valerio 6/A, I-34127 Trieste, Italy.
Background/objectives: The present work proposes a mathematical model able to describe the dissolution of poly-disperse drug spherical particles in a solution (Dissolution Rate Test-DRT). DRT is a pivotal test performed in the pharmaceutical field to qualitatively assess drug bioavailability.
Methods: The proposed mathematical model relies on the key hallmarks of DRT, such as particle size distribution, solubility, wettability, hydrodynamic conditions in the dissolving liquid of finite dimensions, and possible re-crystallization during the dissolution process.
Role of aminophylline in prevention of acute kidney injury in term neonates with severe perinatal asphyxia: a randomized open-label controlled trial.
J Trop Pediatr
October 2024
Department of Health and Family Welfare, Swasthya Bhawan, Kolkata, West Bengal 700091, India.
Article Synopsis
- Acute kidney injury (AKI) is a common complication in neonates who experience severe perinatal asphyxia, and the role of aminophylline in preventing it is debated.
- A study involving 81 severely asphyxiated term neonates evaluated the effectiveness of aminophylline as an adjunct to standard care, showing a lower but not statistically significant incidence of AKI in the aminophylline group compared to the control group.
- While aminophylline treatment seemed to temporarily improve urine output, it did not significantly change renal function or lower AKI rates overall.
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