[Selection of diagnostically significant parameters in integral evaluation of the effects of occupational biologic and chemical hazards].

Clinical and immunologic study including evaluation of immune state, allergic reactivity and adaptation covered 1174 workers engaged into microbiologic synthesis of proteins (production of proteovitamin concentrates and hydrolytic yeast) and 543 ones working at chemical enterprises in contact with gases irritating respiratory tract, with isocyanate and acryl compounds. Homeostasis of the examinees was assessed by means of an integral parameter, and the parameter's limits were defined for the diseases under study. The research determined diagnostically valuable parameters for some entities diagnosed in the examinees. The suggested approach could benefit early diagnosis and prophylaxis of diseases associated with occupational hazards.