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18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Large-Vessel Vasculitis During Active and Inactive Disease Stages Is Associated with the Metabolic Profile, but Not the Macrophage-Related Cytokines: A Proof-of-Concept Study.
Cells
November 2024
Department of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.
Giant cell arteritis (GCA) is an autoimmune/autoinflammatory disease affecting large vessels in patients over 50 years old. The disease presents as an acute inflammatory response with two phenotypes, cranial GCA and large-vessel vasculitis (LV)-GCA, involving the thoracic aorta and its branches. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT) is among the imaging techniques contributing to diagnosing patients with systemic disease.
View Article and Find Full Text PDFAnalysis of musculoskeletal ultrasound findings and cytokines/growth factors in glucocorticoid-resistant polymyalgia rheumatica.
Immunol Med
November 2024
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
We sought to clarify the musculoskeletal ultrasound (MSUS) findings and serum concentrations of cytokines/growth factors in glucocorticoid-resistant polymyalgia rheumatica (GC-R PMR). Patients with PMR admitted to Nagasaki University Hospital ( = 41) were enrolled. MSUS of both shoulder joints was performed in 36 patients.
View Article and Find Full Text PDFStudy on the changes and significance of CXCL10 level in serum of isolated polymyalgia rheumatica.
Clin Rheumatol
December 2024
Department of Rheumatology and Immunology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Article Synopsis
- Researchers aimed to understand the role of CXC chemokine ligand 10 (CXCL10) in isolated polymyalgia rheumatica (PMR) by comparing its serum levels in PMR patients before and after treatment, as well as in rheumatoid arthritis (RA) patients and healthy individuals.
- The study collected and analyzed serum samples from multiple patient groups over several years, using protein microarray technology and enzyme-linked immunosorbent assay (ELISA) to measure various cytokines, particularly focusing on CXCL10.
- Results showed that CXCL10 levels were significantly higher in active PMR patients compared to those in remission, RA patients, and healthy controls, suggesting it may be important in PMR pathogenesis and
Investigating interferon type I responses in patients with suspected giant cell arteritis and polymyalgia rheumatica.
Clin Exp Immunol
November 2024
Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Article Synopsis
- Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory diseases, and researchers are looking for biomarkers to identify active cases and those who may need alternative treatments to glucocorticoids.
- A study evaluated the presence of interferon type I (IFN-I) markers in GCA and PMR patients, including those not previously treated, but did not find significant differences in IFN-I scores between these groups and healthy controls.
- The results indicated that the IFN-I signature and serum markers CXCL10 and Galactin-9 were not elevated in patients with GCA or PMR, suggesting that these IFN-I markers may not be useful for diagnosing or guiding treatment
Diagnostic accuracy of serum biomarkers to identify giant cell arteritis in patients with polymyalgia rheumatica.
RMD Open
August 2024
EFS, INSERM, UMR RIGHT, Franche-Comté University, Besançon, France.
Article Synopsis
- Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) often overlap, but PMR lacks the vascular inflammation present in GCA, suggesting different underlying mechanisms.
- *In a study involving 45 isolated PMR patients and 29 PMR/GCA overlap patients, various serum biomarkers related to inflammation and vascular function were measured to differentiate between the two conditions before starting treatment.
- *Results indicated that certain biomarker ratios, specifically CXCL9/IL-6 and MMP-3/sCD141, were more effective at diagnosing GCA in patients with isolated PMR, demonstrating the potential to guide further examination for those at risk.*
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