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Early events in G-quadruplex folding captured by time-resolved small-angle X-ray scattering.
Nucleic Acids Res
January 2025
Department of Medicine, UofL Health Brown Cancer Center, University of Louisville, Louisville KY, 505 S Hancock St, Louisville, KY 40202, United States.
Time-resolved small-angle X-ray experiments are reported here that capture and quantify a previously unknown rapid collapse of the unfolded oligonucleotide as an early step in the folding of hybrid 1 and hybrid 2 telomeric G-quadruplex structures. The rapid collapse, initiated by a pH jump, is characterized by an exponential decrease in the radius of gyration from 24.3 to 12.
View Article and Find Full Text PDFTargeted seed EMS mutagenesis reveals a bHLH transcription factor underlying male sterility in sorghum.
Genetics
January 2025
Donald Danforth Plant Science Center, St. Louis, MO 63132, USA.
Forward genetic screens of mutant populations are fundamental for functional genomics studies. However, isolating independent mutant alleles to molecularly identify causal genes is challenging in species recalcitrant to genetic manipulation. Here, we demonstrate that classic seed EMS mutagenesis coupled with genome sequencing can overcome this limitation in sorghum.
View Article and Find Full Text PDFEvolutionary dynamics of the B chromosomes in the fish species Valenciennes, 1837 of the Paraná River Basin.
Comp Cytogenet
January 2025
Faculdade de Ciências, Universidade Estadual Paulista (UNESP), Avenida Edmundo Carrijo Coube, Bauru, SP, Brazil Universidade Estadual Paulista (UNESP) Bauru Brazil.
The fish species has an interesting B chromosome system, with three morphological types as acrocentric, metacentric, and submetacentric. However, most cytogenetic studies on this species are restricted to the natural population of the Mogi Guaçu River. Given this, the present work aimed to study the structure karyotypic profile as well as the occurrence of supernumeraries in in several localities in the Paraná River basin, where this species is abundant.
View Article and Find Full Text PDFGlobal insights into the genome dynamics of associated with antimicrobial resistance, virulence, and genomic adaptations among clonal lineages.
Front Cell Infect Microbiol
January 2025
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Background: is a significant cause of healthcare-associated infections, with rising antimicrobial resistance complicating treatment. This study offers a genomic analysis of , focusing on sequence types (STs), global distribution, antibiotic resistance genes, and virulence factors in its chromosomal and plasmid DNA.
Methods: A total of 19,711 genomes were retrieved from GenBank.
Concurrent presence of Staphylococcal Cassette Chromosome types of Meticillin-Resistant in hospital environments and post-operative patients at a hospital in Kathmandu, Nepal.
Infect Prev Pract
March 2025
Central Department of Biotechnology, Tribhuvan University, Kirtipur, Nepal.
Introduction: Meticillin resistant (MRSA) is a major contributor to surgical site infections in post-operative patients. Hospital environments harbor MRSA, contributing to higher risk of nosocomial infections. Meticillin resistance is conferred by acquisition of gene, typically carried on mobile genetic element called Staphylococcal Cassette Chromosome (SCC).
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