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Recent progress of functional nano-chitosan in pharmaceutical and biomedical applications: An updated review.
Int J Biol Macromol
January 2025
Institute of Nutrition, Mahidol University, 999 Phutthamonthon 4 Road, Salaya, Nakhon Pathom 73170, Thailand. Electronic address:
Chitosan is a deacylated derivative of chitin, which is a naturally occurring polysaccharide found in the shells of crustaceans. Chitosan's biocompatibility, physicochemical and mechanical properties qualify it as an excellent candidate for biomedical and pharmaceutical applications. Furthermore, the nanoengineering of chitosan enhances its functional and desirable properties for various applications.
View Article and Find Full Text PDFFingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo.
Clin Exp Pharmacol Physiol
January 2025
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that is currently incurable, highlighting the need for new treatment options.
- This study explored the effects of fingolimod, a drug known for its anti-cancer properties, on C6 rat brain cancer cells using various tests to assess cell survival, proliferation, and apoptosis.
- Results showed that fingolimod significantly reduced cell survival and tumor growth in rats, indicating that it may work by inducing cell cycle arrest and apoptosis in GBM cells.
The heart of healing: Echoes of Sándor Ferenczi's legacy in Jeremy Safran's relational commitments.
Am J Psychoanal
September 2024
, New York, NY, 10016, USA.
In this duet of two voices honoring Jeremy Safran's legacy, the authors celebrate some points of resonance between Sándor Ferenczi's groundbreaking relational interventions and Safran's approach to the therapeutic relationship as the heart of healing. Karen Starr first highlights Ferenczi's now well-known creative experimentation with technique and his emphasis on and care for the relational dimension of psychoanalytic treatment. Jill Bresler then links Safran's career-long dedication to the therapeutic alliance to Starr's introductory remarks, honoring Safran and Ferenczi's shared dedication to expanding options in clinical practice through focus on the relationship.
View Article and Find Full Text PDFModeling the influence of bacteria concentration on the mechanical properties of self-healing concrete (SHC) for sustainable bio-concrete structures.
Sci Rep
April 2024
Department of Civil Engineering, SRM Institute of Science and Technology, Chennai, India.
In this research paper, the intelligent learning abilities of the gray wolf optimization (GWO), multi-verse optimization (MVO), moth fly optimization, particle swarm optimization (PSO), and whale optimization algorithm (WOA) metaheuristic techniques and the response surface methodology (RSM) has been studied in the prediction of the mechanical properties of self-healing concrete. Bio-concrete technology stimulated by the concentration of bacteria has been utilized as a sustainable structural concrete for the future of the built environment. This is due to the recovery tendency of the concrete structures after noticeable structural failures.
View Article and Find Full Text PDFExploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review.
Discov Nano
December 2023
Department of Physics, Karunya Institute of Technology and Sciences, Coimbatore, India.
The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug.
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