With the use of dispersion analysis the variation of indices of central and peripheral hemodynamics in healthy volunteers stayed from 1 to 7 days under conditions of "dry" immersion (DI) was studied. Nine persons were investigated at rest, 5 individuals during orthostatic tests before and after dry immersion sessions. The central hemodynamic indices were calculated, the arterial pressure (AD) was measured by Korotkoff's method, indices of rheoencephalographic and rheoplethysmographic indices of lower leg were found. The significant differences of mean values of measured parameters before and after DI at rest were not revealed. Two-factor dispersion analysis of the orthostatic test data revealed the high levels of significance of influencing immersion and personality factors as well as their interaction on the variation of most indices. For excluding an individual uniformity there has been done an analysis of dynamics of indices according to their relative values which allowed one to isolate qualitative peculiarities of changes and distinctions between persons with different orthostatic tolerance even before orthostatic testing.
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Acta Pharm
December 2024
University of Zagreb Faculty of Pharmacy and Biochemistry 10000 Zagreb, Croatia.
Zeolites are a large family of minerals and the most studied is the naturally occurring clinoptilolite. They possess anti-inflammatory, antioxidant, and detoxifying properties which makes them valuable for medicinal use. Element analysis of zeolite's composition is necessary for its precise chemical characterization, and within this work development of a suspension method for the determination of manga nese, iron, and zinc by total reflection X-ray fluorescence spec-trometry (TXRF) was presented.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Legnaro, Italy.
Nematodes are abundant and ubiquitous animals which are poorly known at intraspecific level. This work represents the first attempt to fill the gap on basic knowledge of genetic variability and differentiation in Protostrongylus oryctolagi, a nematode parasite of lagomorphs. 68 cox1 sequences were obtained from brown hares collected in five locations in Northern and Central Italy, highlighting the presence of a high amount of genetic variation inside this species.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: Neurite degeneration is increasingly suspected to represent a causal feature of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Therefore, sensitive and specific imaging biomarkers of neuronal degeneration are needed to elucidate the mechanisms underlying cognitive impairment in MCI and AD. However, the recently developed Neurite Orientation Dispersion and Density Imaging (NODDI) MRI technique, used to measure the neurite density index (NDI), has some limitations.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Turner Institute for Brain and Mental Health & School of Psychological Sciences, Monash University, Clayton, VIC, Australia.
Background: Plasma and cerebrospinal (CSF) biomarkers are promising candidates for detecting neuropathology. While CSF biomarkers directly reflect pathophysiological processes within the central nervous system, their requirement for a lumbar puncture is a barrier to their widespread scalability in practice. Therefore, we examined cross-sectional associations of plasma biomarkers of amyloid (Aβ42/Aβ40 and pTau-181), neurodegeneration (Neurofilament Light, NfL), and neuroinflammation (Glial Fibrillary Acidic Protein, GFAP) with brain volume, cognition, and their corresponding CSF levels.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) has been mainly thought of as a disease involving gray matter changes. However, despite known correlations between white matter integrity and cognition, less is known about how disruptions to white matter during the development of AD underpin cognitive impairment. This study tests the associations between disruptions to white matter along the AD clinical continuum (cognitive unimpaired (CU): cognitive impaired (CI) - Mild Cognitive Impairment (MCI) and AD) and cognition using diffusion tensor imaging (DTI) and multi-tissue neurite and orientation dispersion and density imaging (mtNODDI) models of the multi-shell connectome diffusion MRI (ms-dMRI) data from the Alzheimer's Disease Connectome Project (ADCP).
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