The paper contains data of the experiment aboard biosatellite Cosmos-2229 which embraced registration of the intracranial pressure (ICP) in primates during space flight. ICP exhibited a small increase (25-30%) comparing with mean values over 20 hours of the prelaunch period and did not go beyond the limits of physiological norm. In the second part of the flight, ICP tended to return to the preflight level. The ICP pulse wave pattern was considerably changed on account of the venous component on the initial days of orbiting and nearly assumed its preflight form further in flight. The diurnal ICP rhythm was found to be gradually altering in the course of the flight.

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