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Mean blood pressure and heart rate have been registered in the experiments on male Wistar rats. Kallikrein-kinin system (KKS) components have been evaluated in blood plasma: plasma kallikreinogen, kallikrein-inhibiting capacity, spontaneous esterase activity. The parameters were determined before and after hemorrhage in the volume accounting for 10, 20 and 30% of the circulating blood volume.
View Article and Find Full Text PDFThe values of depressive humoral factors drastically decrease in healthy subjects and patients with hypertensive disease running with crisis in the areas of hot climate in summer. After arresting hypertensive crises, the levels of kallikreinogen, kallikrein, kininogen increase. In the crises, there is a significant inverse correlation between the blood pressure and blood kallikrein and kininogen concentrations.
View Article and Find Full Text PDFBradikininogen, kallikreinogen, kallikrein, kininase I as well as blood BAEE-esterase and antitryptic activities were studied in development of extensive myocardial infarction in dogs. Some components of kinine system were activated already within 1 hr after ligation of coronary artery, maximal their activation was observed within 3 hrs. In this period content of bradikinin was distinctly decreased--up to 42% of the initial level, kallikrein was activated 8-8-fold, content of kallikreinogen was twice decreased and BAEE esterase activity of blood was increased moderately.
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