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Single-Frequency Birdcage Coils for Deep Tissue Perfluorocarbon Magnetic Resonance Imaging in Mice.
NMR Biomed
January 2025
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
Fluorine-19 (F) MRI has become an established tool for in vivo cell tracking following ex vivo or in vivo labelling of various cell types with F perfluorocarbons (PFCs). Here, we developed and evaluated novel mouse-specific radiofrequency (RF) hardware for improved dual H anatomical imaging and deep tissue F MR detection of PFCs. Three linearly polarized birdcage RF coils were constructed-a dual-frequency H/F coil, and a pair of single-frequency H and F coils, designed to be used sequentially.
View Article and Find Full Text PDFMaternal riboflavin deficiency causes embryonic defects by activating ER stress-induced hepatocyte apoptosis pathway.
Free Radic Biol Med
November 2024
State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. Electronic address:
Article Synopsis
- Riboflavin deficiency (RD) leads to serious issues like liver damage, abnormal embryonic development, and high mortality, but inhibiting ER stress may help rescue these effects.
- In laboratory experiments, treating embryonic duck liver cells with an ER stress inhibitor significantly reduced cell death caused by RD, and similar treatment improved hatchability and development in live embryos compared to untreated RD groups.
- The study suggests that the apoptosis (cell death) triggered by RD is linked to ER stress and the CHOP pathway, highlighting potential targets for therapeutic intervention to mitigate the risks associated with riboflavin deficiency.
[Magnetic induced phase shift detection system based on a novel sensor for cerebral hemorrhage].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
June 2024
Department of Biomedical Engineering and Imaging Medicine, Army Medical University, Chongqing 400038, P. R. China.
The main magnetic field, generated by the excitation coil of the magnetic induction phase shift technology detection system, is mostly dispersed field with small field strength, and the offset effect needs to be further improved, which makes the detection signal weak and the detection system difficult to achieve quantitative detection, thus the technology is rarely used experiments and clinical trials. In order to improve problems mentioned above, a new Helmholtz birdcage sensor was designed. Stimulation experiment was carried out to analyze the main magnetic field in aspects of intensity and magnetic distribution, then different bleeding volume and bleeding rates experiments were conducted to compared with traditional sensors.
View Article and Find Full Text PDFMultiphoton parallel transmission (MP-pTx): Pulse design methods and numerical validation.
Magn Reson Med
October 2024
Harvard Medical School, Boston, Massachusetts, USA.
Purpose: We propose and evaluate multiphoton parallel transmission (MP-pTx) to mitigate flip angle inhomogeneities in high-field MRI. MP-pTx is an excitation method that utilizes a single, conventional birdcage coil supplemented with low-frequency (kHz) irradiation from a multichannel shim array and/or gradient channels. SAR analysis is simplified to that of a conventional birdcage coil, because only the radiofrequency (RF) field from the birdcage coil produces significant SAR.
View Article and Find Full Text PDFA theoretical and experimental investigation on a volume coil with slotted end-rings for rat MRI at 7 T.
MAGMA
December 2023
Department of Electrical Engineering, UAM Iztapalapa, 09340, Mexico City, Mexico.
Objective: A volume coil with squared slots-end ring was developed to attain improved sensitivity for imaging of rat's brain at 7 T.
Material And Methods: The principles of the high cavity resonator for the low-pass case and the law of Biot-Savart were used to derive a theoretical expression of [Formula: see text]. The slotted-end ring resonator showed a theoretical 2.
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