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Application of indocyanine green-human serum albumin complex in fluorescence image-guided laparoscopic anatomical liver resection: study protocol for a randomized controlled trial.
Trials
December 2024
Liver Transplantation Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Background: Indocyanine green (ICG) is a near-infrared fluorescent dye widely used for intraoperative navigation during liver surgeries because of its non-radioactive nature, high safety, and minimal impact on liver function. However, variability in its dosage and concentration and its low imaging success rates have limited its widespread application. To address these issues, we developed a novel ICG-human serum albumin (ICG-HSA) complex to enhance fluorescence visualization during laparoscopic anatomical liver resection.
View Article and Find Full Text PDFTumor specific delivery and radiation-enhanced tumor penetration of mesoporous silica nanoparticles for effective radionuclide therapy of ovarian peritoneal metastasis.
Int J Pharm
December 2024
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA. Electronic address:
Advanced ovarian cancer with peritoneal metastasis is challenging to treat. Limited tumor delivery and penetration of the therapeutics to deep tumor regions are significant barriers to effective treatment. The rising radiopharmaceuticals offer hopes for patients through targeted delivery.
View Article and Find Full Text PDFDevelopment of a sulfidized zerovalent iron-geopolymer composite for the reductive immobilization of ReO.
J Environ Manage
December 2024
Division of Environmental Science and Engineering (DESE), Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea; Division of Advanced Nuclear Engineering (DANE), Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea. Electronic address:
A geopolymer waste form has become a suitable approach for the immobilization of the volatile technetium (Tc) due to the low curing temperature (<60 °C). However, the low retention and the high mobility of the anionic technetium (TcO) remain challenging due to the charge repulsion stemming from the negative charges of the geopolymer surface and the anionic TcO. Herein, a geopolymer composite containing sulfidized nanoscale zerovalent iron (S-nZVI) was developed to reductively immobilize ReO (used as a non-radioactive surrogate for TcO).
View Article and Find Full Text PDFRevisiting sodium phosphotungstate and ammonium molybdate as nonradioactive negative-staining agents for single-particle analysis.
Acta Crystallogr F Struct Biol Commun
December 2024
University of Cologne, Institute of Biochemistry, Faculty of Mathematics and Natural Sciences, Zülpicher Strasse 47, 50674 Cologne, Germany.
This study reports the successful replacement of uranyl-based stains by either sodium phosphotungstate or ammonium molybdate in negative-staining electron microscopy. Using apoferritin as a test specimen, it is demonstrated that in combination with a facile on-grid fixation step, both stains yield comparable images to uranyl formate. Subsequently, using β-galactosidase, it is shown that both stains can also successfully be employed for single-particle analysis, yielding virtually indistinguishable results from uranyl formate.
View Article and Find Full Text PDFMagnetic particle imaging enables nonradioactive quantitative sentinel lymph node identification: feasibility proof in murine models.
Radiol Adv
September 2024
Magnetic Insight Inc., Alameda, CA 94502, United States.
Background: Sentinel lymph node biopsy (SLNB) is an important cancer diagnostic staging procedure. Conventional SLNB procedures with Tc radiotracers and scintigraphy are constrained by tracer half-life and, in some cases, insufficient image resolution. Here, we explore an alternative magnetic (nonradioactive) image-guided SLNB procedure.
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