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Dapagliflozin modulates hepatic lipid metabolism through the proprotein convertase subtilisin/kexin type 9/low density lipoprotein receptor pathway.
Diabetes Obes Metab
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The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is mainly secreted by the liver, and plays a crucial role in lipid metabolism disorder. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) can regulate lipid metabolism through various pathways, including reducing visceral fat accumulation, modulating serum lipoprotein levels and alleviating hepatic steatosis. However, the specific regulatory mechanisms remain unclear.
View Article and Find Full Text PDFEfficacy and safety of consolidative thoracic radiotherapy after first-line chemoimmunotherapy in patients with extensive-stage small-cell lung cancer: a retrospective cohort study.
Transl Lung Cancer Res
December 2024
Department of Radiation Oncology, Taizhou Cancer Hospital, Taizhou, China.
Background: Thoracic radiotherapy (TRT) has shown potential benefits in improving local control and overall survival (OS) in chemotherapy-responsive small-cell lung cancer (SCLC) cases. However, its role in the era of chemoimmunotherapy remains underexplored. In the current era of immunotherapy, this study evaluated the efficacy and safety of consolidative TRT (cTRT) in patients with extensive-stage SCLC (ES-SCLC) and assessed its impact on OS.
View Article and Find Full Text PDFanthelmintic activity of Linn., , Roxb., and Roxb. ethanol extracts on the motility and cuticle damage of .
Vet World
November 2024
Division of Pathology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia.
Background And Aim: , a nematode that frequently infects the digestive tract of chickens, is a significant concern for poultry health. In response, the use of medicinal plant-derived anthelmintics was proposed as a potential solution. This study observed the effectiveness of a single, graded dose of the ethanol extract of , L.
View Article and Find Full Text PDFComparative study of inactivation efficacy of far-UVC (222 nm) and germicidal UVC (254 nm) radiation against virus-laden aerosols of artificial human saliva.
Photochem Photobiol
January 2025
Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Virus-laden aerosols play a substantial role in the spread of numerous infectious diseases, particularly in enclosed indoor settings. Ultraviolet-C (UVC) disinfection is known to be a highly efficient method for disinfecting pathogenic airborne viruses. Recent recommendations suggest using far-UVC radiation (222 nm) emitted by KrCl* (krypton-chloride) excimer lamps to disinfect high-risk public spaces due to lower exposure risks than low-pressure (LP) mercury lamps (254 nm).
View Article and Find Full Text PDFMitochondrial Calcium Homeostasis and Atrial Fibrillation: Mechanisms and Therapeutic Strategies Review.
Curr Probl Cardiol
January 2025
Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China. Electronic address:
Atrial fibrillation (AF) is tightly linked to mitochondrial dysfunction, calcium (Ca²⁺) imbalance, and oxidative stress. Mitochondrial Ca²⁺ is essential for regulating metabolic enzymes, maintaining the tricarboxylic acid (TCA) cycle, supporting the electron transport chain (ETC), and producing ATP. Additionally, Ca²⁺ modulates oxidative balance by regulating antioxidant enzymes and reactive oxygen species (ROS) clearance.
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