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Explainable unsupervised anomaly detection for healthcare insurance data.
BMC Med Inform Decis Mak
January 2025
Department of Electrical Engineering, ESAT-STADIUS, KU Leuven, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium.
Background: Waste and fraud are important problems for health insurers to deal with. With the advent of big data, these insurers are looking more and more towards data mining and machine learning methods to help in detecting waste and fraud. However, labeled data is costly and difficult to acquire as it requires expert investigators and known care providers with atypical behavior.
View Article and Find Full Text PDFSmall bowel lymphangioma: a multidisciplinary approach to diagnostic uncertainty.
BMJ Case Rep
January 2025
General Surgery, Whipps Cross University Hospital NHS Trust, London, UK.
Intra-abdominal lymphangioma, a rare benign lymphatic malformation resulting from an obstruction to lymphatic channels, often has non-specific clinical manifestations. Low incidence rates of this condition, paired with its unusual presentation and ambiguous radiological appearance, commonly lead to diagnostic uncertainty. This pathology can result in significant morbidity and mortality, emphasising the need to achieve early diagnosis and management despite these challenges.
View Article and Find Full Text PDFDeadly mucor at an unusual site: A case report of isolated genital mucormycosis.
Int J Dermatol
January 2025
Department of Pathology, St. John's Medical College, Bangalore, India.
A giant intradiploic epidermoid cyst with an unusual ocular presentation.
J Fr Ophtalmol
January 2025
Department of Ophthalmology, Basaksehir Cam and Sakura City Hospital, University of Health Sciences, 34480 Istanbul, Turkey.
Insights into Heterocycle Biosynthesis in the Cytotoxic Polyketide Alkaloid Janustatin A from a Plant-Associated Bacterium.
Biochemistry
January 2025
Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
Janustatin A is a potently cytotoxic polyketide alkaloid produced at trace amounts by the marine bacterial plant symbiont . Its biosynthetic terminus features an unusual pyridine-containing bicyclic system of unclear origin, in which polyketide and amino acid extension units appear reversed compared to the order of enzymatic modules in the polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) assembly line. To elucidate unknown steps in heterocycle formation, we first established robust genome engineering tools in .
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