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Insertion stability of poly(ethylene glycol)-cholesteryl-based lipid anchors in liposome membranes.
Eur J Pharm Biopharm
June 2016
Institut für Pharmazeutische Wissenschaften, Lehrstuhl für Pharmazeutische Technologie und Biopharmazie, Albert-Ludwigs Universität Freiburg, Hermann Herder Str. 9, 79104 Freiburg, Germany. Electronic address:
Liposomes consist of a hydrophilic core surrounded by a phospholipid (PL) bilayer. In human blood, the half-life of such artificial vesicles is limited. To prolong their stability in the circulation, liposomal bilayers can be modified by inserting poly(ethylene glycol) (PEG) molecules using either PL or sterols as membrane anchors.
View Article and Find Full Text PDFAttomole detection of hemagglutinin molecule of influenza virus by combining an electrochemiluminescence sensor with an immunoliposome that encapsulates a Ru complex.
Anal Chem
June 2008
Department of Environmental Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara-shi, Hiroshima, Japan.
An immunoliposome (80 nm in diameter) encapsulating a Ru complex with two aminobutyl moieties was prepared to detect the presence of hemagglutinin molecules, which play an important role in influenza virus infection. The highly sensitive detection was accomplished by electrochemiluminescence (ECL) from the Ru complex adsorbed onto Au electrodes after competitive immunoreactions. This method clarified that the adsorption of the Ru complex onto the electrode was an important factor in obtaining high sensitivity.
View Article and Find Full Text PDFPreclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification.
Biotechnol Prog
July 2005
SAIC-Frederick, Inc., National Cancer Institute at Frederick, PO Box B, Frederick, Maryland 21702, USA.
A GMP-compliant process is described for producing F5cys-PEG-lipid conjugate. This material fuses with preformed, drug-loaded liposomes, to form "immunoliposomes" that bind to HER2/neu overexpressing carcinomas, stimulates drug internalization, and ideally improves the encapsulated drug's therapeutic index. The soluble, single-chain, variable region antibody fragment, designated F5cys, was produced in E.
View Article and Find Full Text PDFDevelopment of a membrane strip immunosensor utilizing ruthenium as an electro-chemiluminescent signal generator.
Biosens Bioelectron
December 2003
Graduate School of Biotechnology, Korea University, 302 Biotechnology Building, 1, 5-ka, Anam-dong, Sungbuk-ku, Seoul 136-701, South Korea.
A photometric immunosensor that can be used for on-site diagnosis has been constructed. The sensor system was assembled by partially superimposing a nitrocellulose membrane strip (the lower) containing an immobilized antigen on the surface with a glass fiber membrane strip (the upper) including two electrodes on the opposite surfaces. To amplify the signal, we introduced a liposome, containing ruthenium molecules trapped in the core, chemically coupled to an antibody specific to the analyte (e.
View Article and Find Full Text PDFGD2-mediated melanoma cell targeting and cytotoxicity of liposome-entrapped fenretinide.
Int J Cancer
April 1999
Laboratory of Oncology, G. Gaslini Children's Hospital, Genoa, Italy.
Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic index of the drugs.
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