Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Approach to the Patient with Achondroplasia - New Considerations for Diagnosis, Management and Treatment.
J Clin Endocrinol Metab
January 2025
Division of Orthogenetics, Department of Pediatrics, Nemours Children's Hospital, Delaware, 1600 Rockland Road, Wilmington, DE, 19803, USA.
Achondroplasia is the most common disproportionate short-stature skeletal dysplasia. Features associated with achondroplasia are rhizomelia, macrocephaly, midface hypoplasia, and typical cognition. Potential medical complications include foramen magnum stenosis, hydrocephalus, middle ear dysfunction, obstructive and central sleep apnea, spinal stenosis and genu varum.
View Article and Find Full Text PDFMelatonin ameliorates -associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes.
Genes Dis
March 2025
Pediatric Orthopaedic Hospital, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710032, China.
Although the pathogenesis and mechanism of congenital skeletal dysplasia are better understood, progress in drug development and intervention research remains limited. Here we report that melatonin treatment elicits a mitigating effect on skeletal abnormalities caused by deficiency. In addition to our previous finding of endoplasmic reticulum stress upon deficiency, we found calcium (Ca) overload jointly contributed to -associated chondrodysplasias.
View Article and Find Full Text PDFGenu Varum Correction with HA Filler Volumisation of the Medial Gastrocnemius.
Aesthetic Plast Surg
December 2024
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Background: Genu varum, or bow-legged deformity, involves an outward curvature of the lower limbs, often creating a visible gap between the knees when the ankles are together. Traditionally treated with invasive surgical methods like high tibial osteotomy, genu varum correction now includes less invasive options for patients with mild to moderate deformities. This commentary explores a novel approach using hyaluronic acid (HA) filler to volumise the medial gastrocnemius muscle, thereby improving calf contour and stability without surgery.
View Article and Find Full Text PDFAssessment of the Radiographic Angular Parameters in the Coronal Plane of the Lower Limbs in Subjects without Knee Osteoarthritis in a Reference Hospital of the Brazilian Unified Health System.
Rev Bras Ortop (Sao Paulo)
December 2024
Centro de Atenção Especializada do Tratamento da Dismetria e Deformidades do Aparelho Locomotor, Instituto Nacional de Traumatologia e Ortopedia, Rio de Janeiro, RJ, Brasil.
The present study aims to demonstrate the radiological angular parameters of a sample of patients treated at our institution and to compare the radiological abnormalities with other classifications or parameters from the literature. We evaluated a sample of patients submitted to panoramic radiographic examinations of the lower limbs. The inclusion criteria were: (1) Patients without knee osteoarthritis as assessed by an orthopedist.
View Article and Find Full Text PDFWindswept Deformity: A Rare Skeletal Manifestation in an Adolescent with Primary Hyperparathyroidism.
J ASEAN Fed Endocr Soc
December 2024
Department of General Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra, India.
Article Synopsis
- Primary hyperparathyroidism (PHPT) in adolescents is uncommon and typically leads to more severe symptoms than in adults, with skeletal issues being rare and mostly documented in case studies.
- A unique case is reported of a 19-year-old male with a windswept deformity, characterized by the bending of his legs at the knee, who was diagnosed with PHPT after showing elevated calcium and parathyroid hormone levels.
- After identifying and surgically removing a parathyroid adenoma, the patient's calcium and parathyroid hormone levels returned to normal, and he is now scheduled for corrective surgery once his alkaline phosphatase stabilizes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!