The culture pure Pseudomonas sp. CPE1 strain capable of metabolizing low-chlorinated biphenyls in the presence of biphenyl was found to be able to grow on Aroclor 1221 in the absence of an additional carbon source. The presence of glass beads (diameter = 3 mm, 30% w/v) or Triton X-100 (0.066% v/v) in the culture medium significantly enhanced the aerobic dechlorination of the polychlorinated biphenyls present in Aroclor 1221 in batch cultures of CPE1 strain. This result has been ascribed to an increase of Aroclor 1221 bioavailability in the cultures containing glass beads or Triton X-100, probably deriving from a greater interface area PCB-water, i.e. the surface area on which the polychlorobiphenyl degradation seems to take place.
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http://dx.doi.org/10.1016/0045-6535(96)00055-0 | DOI Listing |
Environ Health Perspect
December 2024
Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, Texas, USA.
Background: Increasing evidence supports an association of endocrine-disrupting chemical (EDC) exposures with adverse biological effects in humans and wildlife. Recent studies reveal that health consequences of environmental exposures may persist or emerge across generations. This creates a dual conundrum: that we are exposed to contemporary environmental chemicals overlaid upon the inheritance of our ancestors' exposure profiles.
View Article and Find Full Text PDFEnviron Health Perspect
December 2024
Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, Texas, USA.
Background: Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds that interfere with the normal function of the endocrine system and are linked to direct and inherited adverse effects in both humans and wildlife. Legacy EDCs such as polychlorinated biphenyls (PCBs) are no longer used yet remain detectable in biological specimens around the world; concurrently, we are exposed to newer EDCs like the fungicide vinclozolin (VIN). This combination of individuals' direct environmental chemical exposures and any heritable changes caused by their ancestors' chemical exposures leads to a layered pattern of both direct and ancestrally inherited exposures that might have cumulative effects over generations.
View Article and Find Full Text PDFSci Total Environ
December 2024
Environmental Monitoring Division, City of Los Angeles, 12000 Vista Del Mar, Playa Del Rey, CA 90293, USA; Department of Health Sciences and Sciences, University of California - Los Angeles, Los Angeles, CA 90024, USA. Electronic address:
Polychlorinated biphenyl (PCB) congeners, sold commercially as different mixtures under the trade name Aroclor in the USA, pose ecological and public health hazards. In the environment, they are monitored as Aroclors for potential source tracking and more accurately as congeners to understand the extent of PCB contamination in total. Because of the subjectivity with which Aroclors are currently identified in samples, striving towards clarity is a focus for analytical chemists.
View Article and Find Full Text PDFJ Endocr Soc
November 2024
Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, TX 78712, USA.
Polychlorinated biphenyls (PCBs) pose a global challenge to environmental and human health. Although toxic and carcinogenic at higher exposure levels, at lower concentrations they can act as endocrine-disrupting chemicals. Individuals are more vulnerable to endocrine-disrupting effects of PCB exposures during the perinatal period, when the neuroendocrine system is developing, although assessing the full impact of PCB exposure is difficult because of the often-latent onset of adverse effects.
View Article and Find Full Text PDFReprod Toxicol
September 2023
Department of Comparative Biosciences, University of Illinois, Urbana, IL, USA. Electronic address:
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