The oxidation of low density lipoprotein (LDL) is believed to be an important risk factor for atherosclerosis. We have previously reported that glycation of LDL enhances LDL oxidation. Incubation of LDL in the presence of 200 mM glucose resulted in the enhanced formation of phosphatidylcholine hydroperoxide (PC-OOH) and cholesteryl ester hydroperoxide (CE-OOH). Fe(3+)-ADP accelerated the formation of hydroperoxides. The concentration of PC-OOH was much smaller than that of CE-OOH. In addition, we found a PC-OOH decomposing activity in LDL by following linoleic acid hydroperoxide (18:2-OOH) formation from 1-stearoyl-2-[13'-(S)-hydroperoxy-9', 11'-octadecadienoyl]-sn-glycero-3-phosphocholine (SLPC-OOH). Hydrolysis was similar between LDL and glycated LDL. Pretreatment by para-bromophenacylbromide, histidine modifier and phospholipase A(2) inhibitor, retarded the formation of 18:2-OOH only by 30%. The addition of equimolar platelet activating factor (PAF) reduced hydrolysis by 50%, indicating PAF acetylhydrolase may be responsible for the hydrolysis of PC-OOH.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0005-2760(96)00022-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Newcastle University, Newcastle, Tyne and Wear, United Kingdom.
Background: Approximately 944,000 people are living with dementia in the UK (∼0.8% of the population). The World Health Organisation consider dementia a public health priority.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background: Frontotemporal degeneration (FTD) is an umbrella term encompassing a range of rare neurodegenerative disorders that cause progressive changes to behavior, personality, language, and movement with onset typically before age 60. Currently, several potential FTD therapies are under investigation, underscoring the need for increased diversity in research participation. Two validated scores describe socioeconomic and geographic factors that may impact willingness to participate in research.
View Article and Find Full Text PDFAssessment of lipid peroxidation and total antioxidant capacity in patients with breast cancer.
Explor Target Antitumor Ther
January 2025
Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Aim: Breast cancer (BC), a disease in which abnormal breast cells grow out of control and form tumors, is a prevalent life-threatening disease worldwide. Oxidative stress has been implicated in the development and progression of various cancers, including BC. Assessing lipid peroxidation and overall antioxidant status in BC offers valuable information on disease progression, patient prognosis, and the effectiveness of therapeutic options.
View Article and Find Full Text PDFMortality predictors in acute myocardial infarction: results from a single-center study in Saudi Arabia.
J Med Life
November 2024
Epidemiology and Preventive Medicine Department, National Liver Institute (NLI), Menoufiya University, Shibin Al Kawm, Egypt.
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. Risk factors of mortality in patients with AMI have been widely investigated, identifying older age and heart failure as common contributors. This study aimed to determine risk factors and explore predictors associated with higher mortality among patients with AMI.
View Article and Find Full Text PDFImpact of statin use on COVID-19 outcomes in hospitalized patients in Saudi Arabia: a retrospective cohort study.
J Med Life
November 2024
College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.
There is an increasing requirement for new therapeutic approaches to address lung inflammation caused by COVID-19. Recent evidence suggests that statins may reduce mortality in patients with respiratory infections. This study aimed to investigate the impact of statin use on COVID-19 outcomes among hospitalized patients at Ohud Hospital and King Salman Medical City (KSMC) in Madinah, Saudi Arabia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!