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[Immunization efficacy and safety of 104M against aerosol challenge in BALB/c mice].
Zhonghua Liu Xing Bing Xue Za Zhi
July 2020
Chinese Center for Disease Control and Prevention, Beijing 102206, China.
To evaluate the protective efficacy and safety of 104M against aerosol challenge in BALB/c mice and characterize its immunological effects. Female mice of 6-8 weeks old were immunized with strain 104M by intratracheal aerosol delivery or intranasal instillation or subcutaneous injection route. Six mice of each group were sacrificed at 4, 8, 16, 24 weeks after immunization.
View Article and Find Full Text PDFA safe non-toxic Brucella abortus ghosts induce immune responses and confer protection in BALB/c mice.
Mol Immunol
August 2020
College of Animal Science and Technology, Shihezi University, Shihezi 832003, Xinjiang Province, People's Republic of China. Electronic address:
Brucellosis, which is caused by Brucella spp., is an important zoonotic infectious disease that can cause great hazard to public health and safety. However, the current vaccines have several drawbacks, including residual virulence for animals and humans.
View Article and Find Full Text PDFBrucella abortus S19 rfbD mutant is highly attenuated, DIVA enable and confers protection against virulent challenge in mice.
Biologicals
January 2020
Division of Bacteriology and Mycology, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India. Electronic address:
Brucella abortus S19 is an important tool for controlling bovine brucellosis across the globe. However, vaccination with S19 suffers critical shortcomings such as, presence of residual virulence, induction of abortion and sero-diagnostic interference. In this study, rfbD gene deleted mutant S19 was developed.
View Article and Find Full Text PDFPartial protection induced by Salmonella based Brucella vaccine candidate in pregnant guinea pigs.
Vaccine
February 2019
College of Veterinary Medicine, Chonbuk National University, Iksan Campus, 570-752 Iksan, Republic of Korea. Electronic address:
Residual virulence is a major drawback in current Brucella vaccines. Live vaccines induce abortions in pregnant animals. Hence, a novel anti-Brucella vaccine was developed utilizing rough Salmonella delivering four Brucella antigens.
View Article and Find Full Text PDFThe Brucella melitensis M5-90ΔmanB live vaccine candidate is safer than M5-90 and confers protection against wild-type challenge in BALB/c mice.
Microb Pathog
November 2017
College of Agroforestry Engineering and Planning (Cultural and Technological Industry Innovation Research Center), Tongren University, Tongren 554300, Guizhou, China.
Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. Although effective, the current Brucella vaccines (strain M5-90 or others) have several drawbacks. The first is their residual virulence for animals and humans and the second is their inability to differentiate natural infection from that caused by vaccination.
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