In our previous experiments on animals evidence was found that citrus fragrance can restore the stress-induced immunosuppression, suggesting that citrus fragrance may have an effect on restoring the homeostatic balance. Since a dysregulation of the neuroendocrine and immune function is thought to be associated with psychosomatic or psychiatric disorders an attempt was made to restore their mental health by stimulation of one of the sensory systems. Fragrance (citrus was our choice) which comforts through stimulation of the olfactory system was applied to depressive patients. It was given to 12 depressive subjects and the results indicated that the doses of antidepressants necessary for the treatment of depression could be markedly reduced. The treatment with citrus fragrance normalized neuroendocrine hormone levels and immune function and was rather more effective than antidepressants.
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Article Synopsis
- The study investigates how rising living standards are increasing demand for healthier, sugar-reduced food options, particularly focusing on sweet orange juice and its aroma compounds.
- It identifies 12 key aroma compounds and finds that several, particularly (E)-citral and others, enhance the sweetness of a sugar solution while nonanol does not.
- Molecular docking and dynamics analysis reveal that the stability of the binding between sucrose and sweet taste receptors is improved by (E)-citral, indicating potential for developing novel sweeteners using these aroma substances.
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