Preinvasive laryngeal lesions progress to infiltrating carcinoma in 7-15% of cases. Clinical manifestations and histological findings are not reliably predictive of progression. Quantitative cytometry improves predictive effectiveness, but is not a routine procedure. A clinico-histological scale consisting of 13 variables which were combined and used prospectively had a predictive value of 0.8 sensitivity and 0.9 specificity for progression of preinvasive laryngeal lesions.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis.
Vaccines (Basel)
February 2022
Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.
Objective: To assess evidence on the efficacy of adjuvant human papillomavirus (HPV) vaccination in patients treated for HPV-related disease across different susceptible organ sites.
Methods: A systematic review was conducted to identify studies addressing the efficacy of adjuvant HPV vaccination on reducing the risk of recurrence of HPV-related preinvasive diseases. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI).
Uterine cervical adenosquamous carcinoma in situ was originally defined as having either a uniform population of cells with features intermediate in appearance between glandular and squamous cells, or a mixture of distinct glandular and squamous components within a single lesion. The former type would likely be reclassified today as stratified mucin-producing intraepithelial lesion, while the latter type is vanishingly rare. Here, we report a novel case of bona fide adenosquamous carcinoma in situ, which exhibits 2 morphologically and immunophenotypically distinct components: (1) an inner glandular component composed of a single layer of p40-negative, ciliated, mucin-producing dysplastic columnar cells and (2) an outer p40-positive, stratified dysplastic squamous component otherwise identical to cervical intraepithelial neoplasia-3.
View Article and Find Full Text PDFRole of TFF3 as an adjunct in the diagnosis of Barrett's esophagus using a minimally invasive esophageal sampling device-The Cytosponge.
Diagn Cytopathol
March 2020
Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
The incidence of esophageal carcinoma continues to increase whilst its prognosis remains poor. The most dramatic reduction in mortality is likely to follow early diagnosis of the preinvasive precursor lesion, Barrett's esophagus (BE), coupled with treatment of dysplastic lesions. The major risk factor for BE is gastroesophageal reflux disease, however this is highly prevalent and only a small proportion of individuals have BE, therefore an endoscopy-based screening strategy to detect BE is unfeasible.
View Article and Find Full Text PDFThe predictive value of videostroboscopy in the assessment of premalignant lesions and early glottis cancers.
Otolaryngol Pol
August 2017
Katedra i Klinika Otolaryngologii Warszawskiego Uniwersytetu Medycznego K. Niemczyk.
Objective: To assess the sensitivity and specificity of larngovideostroboscopy (LVS) in the diagnosis of precancerous and malignant lesions of the vocal folds.
Material And Methods: In 175 patients (128 men and 47 women), aged 19-88 years, mean age 61.5, who were admitted to the clinic with diagnosed premalignant conditions of vocal fold mucosa (leukoplakia, chronic hypertrophic inflammatory lesions) and thickening or tumor on the vocal fold, there was performed LVS before the laryngeal microsurgery.
Is severe dysplasia the same lesion as carcinoma in situ? 10-Year follow-up of laryngeal precancerous lesions.
Acta Otolaryngol
March 2012
Department of Pathology, Beijing Tongren Hospital, affiliated to the Capital Medical University, PR China.
Article Synopsis
- The study examined the progression of various precancerous laryngeal lesions (mild, moderate, severe dysplasia, and carcinoma in situ) and concluded that moderate dysplasia behaves similarly to severe dysplasia, but both differ significantly from carcinoma in situ (CIS).
- Data from a 10-year retrospective analysis of 86 patients indicated that 19.8% developed invasive carcinoma, with CIS showing the highest progression rate at 40%.
- Mild dysplasia was found not to be precancerous, and the study emphasized the need for aggressive management of patients with CIS rather than other types of lesions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!