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Pharmacological inhibition of lipid peroxidative damage by the 21-aminosteroid U-74389G improves cortical mitochondrial function following traumatic brain injury in young adult male rats.
Neuropharmacology
June 2020
Spinal Cord & Brain Injury Research Center (SCoBIRC), 741 S. Limestone St, Lexington, KY, 40536-0509, USA; Department of Neuroscience, 800 Rose St, Lexington, KY, 40536-0298, USA. Electronic address:
The 21-aminosteroid ("lazaroid") U-74389G (U74), an inhibitor of lipid peroxidation (LP), was used to protect mitochondrial function following TBI in young adult male rats. The animals received a severe (2.2 mm) controlled cortical impact-TBI.
View Article and Find Full Text PDFRole of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment.
Drugs Aging
April 2002
Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore.
Free radicals and other so-called 'reactive species' are constantly produced in the brain in vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of electrons from the mitochondrial electron transport chain to generate superoxide radical (O2*-). Others are generated for useful purposes, such as the role of nitric oxide in neurotransmission and the production of O2*- by activated microglia.
View Article and Find Full Text PDFEffects of dietary restriction and antioxidants on presbyacusis.
Laryngoscope
May 2000
Department of Otolaryngology-Head and Neck Surgery, Henry Ford Health System, West Bloomfield, Michigan 48323, USA.
Objectives/hypothesis: The premise of this study is that the membrane hypothesis of aging, also known as the mitochondrial clock theory of aging, is the basis for presbyacusis. Furthermore, it is proposed that treatment with antioxidants or dietary restriction can attenuate age-related hearing loss. Many studies have demonstrated a reduction in blood flow to specific tissues, including the cochlea, with aging.
View Article and Find Full Text PDFReactive oxygen metabolites, antioxidants and head and neck cancer.
Head Neck
August 1999
Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, 6777 W. Maple Road, W. Bloomfield, MI 48323, USA.
This manuscript will review the probable role of reactive oxygen metabolites (ROM) in the etiopathogenesis of head and neck cancer (HNC). Cancer is a heterogeneous disorder with multiple etiologies including somatic and germ-line mutations, cellular homeostatic disturbances, and environmental triggers. Certain etiologies are characteristic of HNC and include infectious agents such as the Epstein-Barr virus, the use of tobacco, and consumption of alcohol.
View Article and Find Full Text PDFAltered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy.
Kidney Int
October 1997
Division of Nephrology and Hypertension, University of California, Irvine, USA.
Chronic exposure to low levels of lead results in sustained hypertension (HTN) in humans and experimental animals. The mechanism of lead-induced HTN remains unclear. We investigated the possible role of reactive oxygen species (ROS) and their impact on nitric oxide (NO) metabolism in lead-induced HTN.
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