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Novel peptide inhibitor of matrix Metalloproteinases-1 from pufferfish skin collagen hydrolysates and its potential Photoprotective activity via the MAPK/AP-1 signaling pathway.
J Photochem Photobiol B
December 2024
Fisheries Research Institute of Fujian, National Research and Development Center for Marine Fish Processing, Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province, Xiamen, China. Electronic address:
Takifugu bimaculatus, a pufferfish species farmed in Fujian Province, is known for its non-toxic flesh and collagen-rich skin. We identified a novel collagen-derived matrix metalloproteinase 1 (MMP-1) inhibitory peptide, from T. bimaculatus skin with potent anti-photoaging properties.
View Article and Find Full Text PDFOxytocin-mediated social preference and socially reinforced reward learning in the miniature fish Danionella cerebrum.
Curr Biol
December 2024
Department of Neurobiology, University of Utah, 20 S 2030 E, BPRB 490D, Salt Lake City, UT 84112, USA. Electronic address:
Integrative studies of diverse neuronal networks that govern social behavior are hindered by a lack of methods to record neural activity comprehensively across the entire brain. The recent development of the miniature fish Danionella cerebrum as a model organism offers one potential solution, as the small size and optical transparency of these animals make it possible to visualize circuit activity throughout the nervous system. Here, we establish the feasibility of using Danionella as a model for social behavior and socially reinforced learning by showing that adult fish exhibit strong affiliative tendencies and that social interactions can serve as the reinforcer in an appetitive conditioning paradigm.
View Article and Find Full Text PDFImpact of late-stage hypoxic stimulation and layer breeder age on embryonic development, hatching and chick quality.
Poult Sci
December 2024
Laboratory of Regional Center of Excellence for Poultry Science, University of Lomé, 01 BP 1515, Lomé, Togo.
The present study examined the effects of breeder age and oxygen (O₂) concentrations during the late chorioallantoic membrane (CAM) growth stage on embryo development, hatching dynamics, chick quality, bone mineralization and hatchability. A total of 1200 eggs from 33- and 50-week-old ISA layer breeders, weighing 53.85 g and 60.
View Article and Find Full Text PDFExploring the gut microbiota and metabolome of Lateolabrax japonicus: A multi-omics approach.
Comp Biochem Physiol Part D Genomics Proteomics
December 2024
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, People's Republic of China. Electronic address:
The intestinal microbiota plays a crucial role in the health and development of fish, engaging in intricate interactions with the host organism. As a significant species in aquaculture, Lateolabrax japonicus serves as an exemplary model for investigating these interactions and their subsequent effects on growth and health. This study utilized a multi-omics approach, incorporating metagenomic sequencing and non-targeted metabolomics, to delineate the gut microbiota and metabolome of L.
View Article and Find Full Text PDFAim: To study the adverse reactions that develop as a result of complex antibiotic therapy in patients with non-tuberculous lung mycobacterial (NTML) and to determine methods for their elimination without compromising the effectiveness of NTML treatment.
Materials And Methods: Examined 147 patients with confirmed NTML, for which they received treatment in accordance with the results of drug susceptibility of the pathogen. Before and during treatment, a study of clinical, biochemical blood tests, urinalysis, electrocardiogram, external respiration function, ultrasound of the abdominal organs and kidneys was performed.
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