Mercury sphygmomanometers are the gold standard in blood pressure (BP) measurement. However, white coat hypertension can only be diagnosed by using either continuous ambulatory monitoring or home BP recording. Between 10% and 20% of patients under treatment for hypertension have white coat hypertension and most do not need medication. There have been no reports from general practice in the UK of the use of home recording which seems well suited to it. The aim of this study was to confirm the feasibility of carrying out validation procedures of a UA751 semi-automatic sphygmomanometer and to use it to diagnose white coat hypertension in one practice. Firstly, the validation consisted of tests based on the British Hypertension Societies (BHS) published methods. Simultaneous BP measurements were made with the UA751 and a mercury sphygmomanometer, using a t-tube, of 45 random normotensive and hypertensive patients. Validation readings were mercury instrument means 155/83 (s.d.s 25 and 11), UA751 means 156/85 (s.d.s 25 and 10). The proportion of acceptable differences between the readings placed the UA751 in the BHS Guidelines Grade 'B'. Secondly, to detect white coat hypertension, 52 consecutive new or poorly controlled hypertensive patients took a series of home BP readings. Five patients with white coat hypertension were found. We concluded that it is feasible to use the UA751 to diagnose white coat hypertension in general practice where most hypertensive patients are exclusively managed. Used for this specific purpose, it would be extremely cost effective, precluding many patients from unnecessary medication and saving substantial costs in drugs and other resources.
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Egypt Heart J
December 2024
Department of Internal Medicine, HIND Institute of Medical Sciences, Barabanki, India.
Background: Hypertension is a leading cause of premature mortality and morbidity. Recent guidelines advocate for out-of-office blood pressure monitoring, including ambulatory and home BP monitoring, to better identify hypertension phenotypes like masked hypertension, white coat hypertension, and sustained hypertension. However, clinical inertia persists due to a lack of robust evidence on the effectiveness of screening these phenotypes and their association with cardiovascular and all-cause mortality.
View Article and Find Full Text PDFJ Family Med Prim Care
November 2024
Department of Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Center, Saudi Arabia.
Background: Out-of-office blood pressure (BP) measurement devices, such as ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM), enhance the accuracy and reliability of BP readings, detecting white-coat and masked hypertension. The American Heart Association (AHA) advises confirming hypertension diagnoses with ABPM to prevent overdiagnosis, emphasizing the importance of precise out-of-office diagnostic tools. This study aimed to 1) explore the prevalence of ABPM and HBPM use prior to hypertension diagnosis; 2) assess the adherence to AHA recommendations regarding ABPM utilization; and 3) investigate the association between patient characteristics and out-of-office BP monitoring practices.
View Article and Find Full Text PDFCurr Med Res Opin
December 2024
Atherosclerosis and Vascular Biology Laboratory (Aterolab), Division of Cardiology, State University of Campinas (Unicamp), Sao Paulo, Brazil.
Background: White coat effect (WCE) is a phenomenon linked to increased cardiovascular risk, where office blood pressure readings exceed home or ambulatory measurements. Excess weight and elevated blood pressure or glucose are associated with WCE in type 2 diabetes (T2D). This study compared dapagliflozin and glibenclamide on WCE in T2D patients under equivalent blood pressure and glucose control.
View Article and Find Full Text PDFCattle have been selectively bred for coat color, spotting, and depigmentation patterns. The assumed autosomal dominant inherited genetic variants underlying the characteristic white head of Fleckvieh, Simmental, and Hereford cattle have not been identified yet, although the contribution of structural variation upstream the gene has been proposed. Here, we construct a graph pangenome from 24 haplotype assemblies representing seven taurine cattle breeds to identify and characterize the white head-associated locus for the first time based on long-read sequencing data and pangenome analyses.
View Article and Find Full Text PDFAnimals (Basel)
December 2024
College of Animal Science and Technology, Ningxia University, Yinchuan 750021, China.
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