AI Article Synopsis
- The study focused on the expression levels of the interleukin-4 receptor (IL-4R) in leukemic cells from adult T-cell leukemia (ATL) patients compared to normal lymphocytes and other leukemic cells.
- ATL cells showed significantly higher levels of IL-4R expression without any prior stimulation, particularly in acute ATL patients.
- The findings suggest that the abnormal IL-4R expression in ATL may contribute to the proliferation of leukemic cells and the progression of the disease, highlighting potential differences in biological activities compared to other leukemia types.
Article Abstract
We studied the expression of the receptor of interleukin (IL-4), one of the T cell growth factors, on fresh peripheral blood leukemic cells from adult T-cell leukemia (ATL) patients. Flow cytofluorometric analysis with a monoclonal antibody to the IL-4 receptor (IL-4R) were used to investigate whether expression of IL-4R on ATL cells is different from that on normal lymphocytes and other types of leukemic cells. Leukemic cells from acute type ATL patients synthesize IL-4R without stimulation, at levels much higher than normal resting lymphocytes and other types of leukemic cells. Furthermore, leukemic cells from acute type ATL showed higher IL-4R expression than that of chronic type ATL or human T-cell leukemia virus type I carriers. In addition, there was correlation between expression of IL-4R on the cell surface and the proliferative response to IL-4. Both IL-4 and IL-2 induced upregulation of IL-4R on activated normal T cells but not on ATL cells. These results suggest that abnormal expression of IL-4R may display different biological activities in ATL compared with other types of leukemia. Furthermore, the high expression of IL-4R in ATL may be involved in the proliferation of leukemic cells and the leukemogenesis in this disease.
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| http://dx.doi.org/10.1111/j.1600-0609.1996.tb01936.x | DOI Listing |
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