AI Article Synopsis
- The study investigated the effects of neonatal ethanol exposure on three groups of male Wistar rats and assessed whether reduced glutathione could mitigate these effects.
- Ethanol exposure led to weight loss, decreased emotional responses, reduced spontaneous movement, and difficulties in learning tasks, which were not improved by glutathione administration.
- However, when glutathione was administered to the mothers of the ethanol-exposed group, it significantly enhanced the rats' learning abilities and emotional scores at three months old, although it did not affect their spontaneous movement.
Article Abstract
The study was performed on three groups of male rats of the Wistar strain at the age of three months: group 1 (n = 10), the control group; group 2 (n = 10), consisting of animals treated neonatally (from day 4 through day 10) with ethanol 20%, administered by gavage to the mothers, at the dose of 5 g/kg body/day; group 3 (n = 10) of animals exposed to ethanol under similar conditions, but whose mothers have been injected a reduced glutathione (TAD-600) solution in a dose of 2 mg/100 g body weight of the mother. All the animals were weight ed before the test of behavior. The neonatal administration of ethanol caused ponderal weight retardation, which was not influenced by TAD-600 administrations. Also, a decrease in the scores of emotivity and spontaneous motility in the open field was noticed, as well as difficulties in the acquisition of active avoidance conditioned reflexes in the shuttle-box. Concomitant glutathione administration during the neonatal period significantly improves the learning ability at the age of three months, as well as the score of emotivity, without improving the spontaneous motility score.
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