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Metabolomic and gene networks approaches reveal the role of mitochondrial membrane proteins in response of human melanoma cells to THz radiation.
Biochim Biophys Acta Mol Cell Biol Lipids
January 2025
Budker Institute of Nuclear Physics SB RAS, Acad. Lavrentiev Ave.,9, 630090 Novosibirsk, Russia.
Terahertz (THz) radiation has gained attention due to technological advancements, but its biological effects remain unclear. We investigated the impact of 2.3 THz radiation on SK-MEL-28 cells using metabolomic and gene network analysis.
View Article and Find Full Text PDFMetabolomics with gut microbiota analysis of podophyllotoxin-mediated cardiotoxicity in mice based on the toxicological evidence chain (TEC) concept.
Chem Biol Interact
January 2025
Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine, Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China. Electronic address:
Podophyllotoxin (PPT) is a lignan isolated from the traditional Chinese medicine Dysosma Versipellis, with significant anti-tumor activity. However, its cardiotoxicity restricts its clinical application. This study aims to investigate the cardiotoxicity of PPT in mice and its underlying mechanisms based on the concept of toxicological evidence chain (TEC).
View Article and Find Full Text PDFSex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.
Commun Biol
December 2024
Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany.
Early life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to explore how sex differences influence the genetic and metabolic neurobiological pathways underlying trauma-related behaviors. This study uses the limited bedding and nesting (LBN) paradigm to model ELS and investigate its sex-specific effects on fear memory formation.
View Article and Find Full Text PDFWild-Type Domestication: Loss of Intrinsic Metabolic Traits Concealed by Culture in Rich Media.
Microb Ecol
November 2024
Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Bacteria are typically isolated on rich media to maximise isolation success, removing them from their native evolutionary context. This eliminates selection pressures, enabling otherwise deleterious genomic events to accumulate. Here, we present a cautionary tale of these 'quiet mutations' which can persist unnoticed in bacterial culture lines.
View Article and Find Full Text PDFAdvances in base editing: A focus on base transversions.
Mutat Res Rev Mutat Res
December 2024
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, China; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, China; "Chuangxin China" Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong 250021, China. Electronic address:
Article Synopsis
- * Two early types of BEs, cytosine base editor (CBE) and adenine base editor (ABE), can correct common base transitions that account for about half of disease-causing SNVs.
- * New base transversion editors have been created to address the remaining SNVs that can't be corrected by BEs, but these transversion editors are still in early development compared to transition editors.
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