Two Bacillus subtilis genes, designated resD and resE, encode proteins that are similar to those of two-component signal transduction systems and play a regulatory role in respiration. The overlapping resD-resE genes are transcribed during vegetative growth from a very weak promoter directly upstream of resD. They are also part of a larger operon that includes three upstream genes, resABC (formerly orfX14, -15, and -16), the expression of which is strongly induced postexponentially. ResD is required for the expression of the following genes: resA, ctaA (required for heme A synthesis), and the petCBD operon (encoding subunits of the cytochrome bf complex). The resABC genes are essential genes which encode products with similarity to cytochrome c biogenesis proteins. resD null mutations are more deleterious to the cell than those of resE. resD mutant phenotypes, directly related to respiratory function, include streptomycin resistance, lack of production of aa3 or caa3 terminal oxidases, acid accumulation when grown with glucose as a carbon source, and loss of ability to grow anaerobically on a medium containing nitrate. A resD mutation also affected sporulation, carbon source utilization, and Pho regulon regulation. The data presented here support an activation role for ResD, and to a lesser extent ResE, in global regulation of aerobic and anaerobic respiration i B.subtilis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC177812PMC
http://dx.doi.org/10.1128/jb.178.5.1374-1385.1996DOI Listing

Publication Analysis

Top Keywords

aerobic anaerobic
8
anaerobic respiration
8
bacillus subtilis
8
carbon source
8
resd
7
genes
6
regulators aerobic
4
respiration bacillus
4
subtilis bacillus
4
subtilis genes
4

Similar Publications

Background: Exercise and its effect on cardiovascular diseases have been extensively studied in the elderly population. The difference in blood pressure (BP) between fit and unfit subjects can be >5 mmHg. It is not well established whether the positive effects of exercising on BP are associated with exercise type, be it aerobic or anaerobic (maximal muscle strength).

View Article and Find Full Text PDF

FAM107A Inhibits the Growth, Invasion and Aerobic Glycolysis of LUAD Cells by Regulating CRYAB/PI3K/AKT.

Biochem Genet

January 2025

Department of Cardiac Function, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, Hubei, China.

Lung adenocarcinoma (LUAD) is characterized by its aggressive nature and resistance to treatment. FAM107A is a tumor suppressor gene that has been found to possess inhibitory effects in several cancers, but its role in LUAD remains unclear. This study investigated the role of FAM107A in regulating LUAD cell growth, invasion and aerobic glycolysis and also investigated the potential underlying mechanisms.

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

University of Miami, Coral Gables, FL, USA.

Background: Cerebral blood flow is decreased in mouse models and patients of Alzheimer's disease (AD). We identified that about 2% of cortical capillaries in the APP/PS1 mouse model of AD had stalled blood flow due to neutrophils obstructing capillaries and contributing to vascular inflammation. Neutrophils are more reactive in AD.

View Article and Find Full Text PDF

In soil polluted with benzene, toluene, ethylbenzene, and xylenes (BTEX), oxygen is rapidly depleted by aerobic respiration, creating a redox gradient across the plume. Under anaerobic conditions, BTEX biodegradation is then coupled with fermentation and methanogenesis. This study aimed to characterize this multi-step process, focusing on the interactions and functional roles of key microbial groups involved.

View Article and Find Full Text PDF

How biofilm and granular sludge cope with dissolved oxygen exposure in anammox process: Performance, bioaccumulation characteristics and bacterial evolution.

J Environ Manage

December 2024

Department of Environmental Science and Engineering, Zhejiang Ocean University, No.1 Haida South Road, Zhoushan, 316022, PR China; Zhejiang Provincial Key Laboratory of Petrochemical Environmental Pollution Control, Zhoushan, 316022, PR China. Electronic address:

In order to study the resistance mechanisms of biofilm and granular sludge to various dissolved oxygen (DO) exposures in anaerobic ammonium oxidation (anammox) process, a biofilm - granular sludge anammox reactor was established and operated. Experimental results showed that DO levels of ≤0.41 mg L hardly affected the total nitrogen removal efficiency (TNRE).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!