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Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis.
Gut Microbes
December 2025
Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Atherosclerosis is the primary cause of cardiovascular and cerebrovascular diseases. However, current anti-atherosclerosis drugs have shown conflicting therapeutic outcomes, thereby spurring the search for novel and effective treatments. Recent research indicates the crucial involvement of oral and gastrointestinal microbiota in atherosclerosis.
View Article and Find Full Text PDFRevolutionizing dental research in the Pacific Islands: the Pacific Islands dental research framework.
Front Oral Health
January 2025
School of Dentistry and Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.
Traditional dental research paradigms often lack relevance in marginalized cultural contexts due to inherent biases and misalignment with local values. For Pacific Islanders, this issue is pronounced, as they face serious oral health challenges while remaining underrepresented in scientific discourse. In response, the authors developed the Pacific Islands Dental Research Framework (PIDRF), a culturally informed, community-driven model that directly addresses these limitations in conventional Western approaches.
View Article and Find Full Text PDFLong-acting nifedipine in the management of essential hypertension: a review for cardiologists.
Am J Cardiovasc Dis
December 2024
J.B. Chemicals and Pharmaceuticals Ltd. Cnergy It Park, Unit A, Appasaheb Marathe Marg, Century Bazaar, Prabhadevi, Mumbai, Maharashtra 400025, India.
Calcium channel antagonists, specifically long-acting nifedipine formulations, play a crucial role in treating hypertension and angina. Originally used for angina, nifedipine has been widely employed as an antihypertensive medication for over 40 years. It offers rapid action and oral bioavailability with minimal maternal or fetal side effects, making it suitable for treating hypertensive crises during pregnancy.
View Article and Find Full Text PDFDopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction.
Adv Sci (Weinh)
January 2025
Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Feeding behavior changes induced by opioid addiction significantly contribute to the worsening opioid crisis. Activation of the reward system has shown to provoke binge eating disorder in individuals with opioid use disorder, whereas prolonged opioid exposure leads to weight loss. Understanding the mechanisms underlying these phenomena is essential for addressing this pressing societal issue.
View Article and Find Full Text PDFAssociation Between Oral Health Status and DMFT Index with Cognitive Dysfunction in Community-Dwelling Older Adults with Type 2 Diabetes: A Cross-Sectional Study.
Exp Aging Res
January 2025
Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Objective: Cognitive dysfunction is a significant issue in old age and can cause many problems in older adults, especially those with diabetes. This study aimed to investigate the association between oral health status and DMFT index with cognitive dysfunction in community-dwelling older adults with T2D (type 2 diabetes).
Methods: This was a cross-sectional study that included 245 older people aged 60 years and older with T2D, visiting healthcare centers in north of Iran, using the cluster sampling method.
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