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Cholesteryl ester transfer protein gene polymorphisms are associated with coronary artery disease in Corsican population (France).
Exp Mol Pathol
August 2007
Department of Human Genetics, University of Corsica, Faculty of Science, BP52 20250 Corte Corsica, France.
The aim of the present study was to investigate the association between coronary artery disease (CAD) and Cholesterol Ester Transfer Protein (CETP) (gaaa)n polymorphisms of the CETP gene in Central Corsica island (France). The study group was composed by 300 unrelated Corsican patients with angiographically documented CAD and 300 unrelated healthy blood donors. Significant differences were observed in the distribution of CETP (gaaa)n alleles between the groups under study (p=0.
View Article and Find Full Text PDFEvidence for circulating bone marrow-derived endothelial cells.
Blood
July 1998
Department of Surgery, The Hope Heart Institute and Providence Medical Center, Seattle, WA 98122, USA.
It has been proposed that hematopoietic and endothelial cells are derived from a common cell, the hemangioblast. In this study, we demonstrate that a subset of CD34(+) cells have the capacity to differentiate into endothelial cells in vitro in the presence of basic fibroblast growth factor, insulin-like growth factor-1, and vascular endothelial growth factor. These differentiated endothelial cells are CD34(+), stain for von Willebrand factor (vWF), and incorporate acetylated low-density lipoprotein (LDL).
View Article and Find Full Text PDFA class of highly polymorphic tetranucleotide repeats for canine genetic mapping.
Mamm Genome
May 1996
Program in Transplantation Biology, Clinical Research Division, M318, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104, USA.
We have identified and characterized a new class of polymorphic markers for the canine genome from a simple tetranucleotide repeat sequence, (GAAA)n. Genetic markers derived from this repeat are highly polymorphic compared with other canine microsatellites, yet are stable enough to be useful for following Mendelian inheritance in multigeneration pedigrees. We show further that (GAAA)n repeats are distributed throughout the canine genome and occur with sufficient frequency to be useful in the development of a framework map of the canine genome.
View Article and Find Full Text PDFA polymorphic (GAAA)n microsatellite in a canine Wilms tumor 1 (WT1) gene intron.
Anim Genet
February 1996
Department of Veterinary Pathology, University of Missouri, Columbia 65211, USA.
Characterization and genetic mapping of simple repeat sequences in the tomato genome.
Mol Gen Genet
January 1996
Department of Plant Breeding and Biometry, Cornell University, Itahaca, NY 14853, USA.
Tomato genomic libraries were screened for the presence of simple sequence repeats (SSRs) with seventeen synthetic oligonucleotide probes, consisting of 2- to 5-basepair motifs repeated in tandem. GAn and GTn sequences were found to occur most frequently in the tomato genome (every 1.2 Mb), followed by ATTn and GCCn (every 1.
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