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A Novel Approach to Peripheral Nerve Regeneration: Local FK-506 Delivery Using a Reservoir Flap Model.
Yonsei Med J
December 2024
Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea.
Purpose: Peripheral nerve injuries can lead to lasting functional impairments, impacting movement and quality of life. FK-506, a widely used immunosuppressant, has demonstrated potential in promoting nerve regeneration in addition to its immunosuppressive effects. This study investigates the use of a local reservoir flap to deliver FK-506 directly to the nerve injury site, aiming to enhance nerve regeneration while minimizing systemic immunosuppression.
View Article and Find Full Text PDFTacrolimus-induced posterior reversible encephalopathy syndrome following liver transplantation.
World J Transplant
June 2024
Division of Gastroenterology and Hepatology, East Carolina University/Brody School of Medicine, Greenville, NC 27858, United States.
Article Synopsis
- The editorial discusses a condition called posterior reversible encephalopathy syndrome (PRES) that can happen to people who have had liver transplants and are treated with a medicine called Tacrolimus.
- Tacrolimus helps prevent the body from rejecting the new liver, but it can cause problems like PRES, which leads to symptoms like high blood pressure, seizures, and vision issues.
- The article emphasizes that doctors need to recognize and diagnose PRES early to help patients feel better and manage the risks from using Tacrolimus.
Post-transplant lymphoproliferative disorder associated Epstein-Barr virus DNAemia after liver transplantation in children: Experience from single center.
J Med Virol
June 2024
Division of Gastroenterology, Hepatology, and Nutrition Disease, Department of Pediatrics, Medical School of Ege University, İzmir, Türkiye.
Article Synopsis
- Post-transplant lymphoproliferative disorder (PTLD) is a serious complication that can occur after solid organ transplants, particularly in pediatric liver transplant recipients.
- A study conducted on 112 pediatric patients revealed that 43.75% developed Epstein-Barr virus (EBV) DNAemia, with 8 of these patients subsequently diagnosed with PTLD.
- Findings showed that age at diagnosis of EBV DNAemia, as well as abnormal test results, were significantly higher in PTLD patients, indicating a correlation between older age and the development of this complication.
Optimum tacrolimus trough levels for enhanced graft survival and safety in kidney transplantation: a retrospective multicenter real-world evidence study.
Int J Surg
October 2024
Division of Transplantation and Vascular Surgery, Department of Surgery, Seoul National University Hospital, Seoul.
Article Synopsis
- The study investigates the best tacrolimus trough levels to maximize kidney transplant success and minimize patient risks across a large cohort of 11,868 recipients from five medical centers.
- Findings suggest that maintaining tacrolimus levels between 5.0-7.9 ng/mL in the first two years post-transplant decreases risks of graft failure and severe complications like infections and malignancies.
- The research supports specific tacrolimus dosage guidelines, aiming to improve long-term outcomes for kidney transplant patients.
The Role of FKBPs in Complex Disorders: Neuropsychiatric Diseases, Cancer, and Type 2 Diabetes Mellitus.
Cells
May 2024
Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, The Zlotowski Center for Neuroscience and Zelman Center-The School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Stress is a common denominator of complex disorders and the FK-506 binding protein (FKBP)51 plays a central role in stress. Hence, it is not surprising that multiple studies imply the involvement of the FKBP51 protein and/or its coding gene, , in complex disorders. This review summarizes such reports concentrating on three disorder clusters-neuropsychiatric, cancer, and type 2 diabetes mellitus (T2DM).
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