Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A Newly Synthesized Benzimidazolium Salt: 1-(2-Cyanobenzyl)-3-(4-Vinylbenzyl)-1H-Benzo[D]imidazol-3-ium Chloride as a Potential Anticancer Agent for Colon Cancer Treatment, In Vitro Study.
J Biochem Mol Toxicol
January 2025
Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye.
Colon cancer is one of the most common cancer-related deaths. Drug resistance is one of the biggest challenges in cancer treatment. Numerous pharmacological and biochemical investigations have documented the benzimidazole ring's anticancer, anti-inflammatory, and antioxidant properties.
View Article and Find Full Text PDFThe development of murine bone marrow-derived mast cells expressing functional human MRGPRX2 for and studies.
Front Immunol
January 2025
Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Introduction: A subtype of human mast cells (MCs) found in the skin and to a lesser extent in the lung and gut express a novel G protein-coupled receptor (GPCR) known as Mas-related GPCR-X2 (MRGPRX2, mouse counterpart MrgprB2). In addition to drug-induced pseudoallergy and cutaneous disorders, MrgprB2 contributes to ulcerative colitis, IgE-mediated lung inflammation and systemic anaphylaxis. Interestingly, most agonists activate MRGPRX2 with higher potency than MrgprB2.
View Article and Find Full Text PDFUsing large language models for extracting stressful life events to assess their impact on preventive colon cancer screening adherence.
BMC Public Health
January 2025
Biomedical Informatics Center, Department of Public Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC, USA.
Background: Increase in early onset colorectal cancer makes adherence to screening a significant public health concern, with various social determinants playing a crucial role in its incidence, diagnosis, treatment, and outcomes. Stressful life events, such as divorce, marriage, or sudden loss of job, have a unique position among the social determinants of health.
Methods: We applied a large language model (LLM) to social history sections of clinical notes in the health records database of the Medical University of South Carolina to extract recent stressful life events and assess their impact on colorectal cancer screening adherence.
Nucleotide metabolism-associated drug resistance gene NDUFA4L2 promotes colon cancer progression and 5-FU resistance.
Sci Rep
January 2025
Department of Colorectal Surgery, Clinical Oncology School of Fujian Medical University, Fuzhou, 350004, Fujian, Fujian, P.R. China.
Article Synopsis
- Chemotherapy significantly improves prognosis for colorectal cancer patients, but resistance to drugs like 5-Fluorouracil (5-FU) is a growing problem.
- Research identified that nucleotide metabolism may play a key role in both cancer progression and drug resistance, leading to the development of a risk score model to predict patient outcomes.
- The study found that the gene NDUFA4L2 enhances colon cancer cell growth and movement, contributing to resistance against 5-FU, highlighting its potential as a target for improving treatment strategies.
Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis.
NPJ Sci Food
January 2025
College of Agriculture, Yabian University, Yanji, 133002, China.
To investigate the anti-inflammatory effects of collagen peptides, collagen peptides from cod skin were prepared to assess their in vitro anti-inflammatory effects and in vivo efficacy against ulcerative colitis. The results show that collagen peptides demonstrated anti-inflammatory effects by inhibiting the secretion of pro-inflammatory cytokines and reducing oxidative stress in vitro. In vivo, collagen peptides significantly reduced colonic tissue damage, modulated serum cytokine balance, increased the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in colon tissue, enhanced the abundance of beneficial bacteria while reducing harmful bacteria, and restored microbial balance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!