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Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia.
Circ Res
January 2025
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (C.P., S.A., J.W.A., R.L., F.N., J.S., I.C.).
Background: Iron is an essential micronutrient for cell survival and growth; however, excess of this metal drives ferroptosis. Although maternal iron imbalance and placental hypoxia are independent contributors to the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, the mechanisms by which their interaction impinge on maternal and placental health remain elusive.
Methods: We used placentae from normotensive and preeclampsia pregnancy cohorts, human H9 embryonic stem cells differentiated into cytotrophoblast-like cells, and placenta-specific preeclamptic mice.
Proper nutrition is vital for maintaining good health for all people across their lifespan, especially children and mothers, who are especially vulnerable due to their specific nutrient needs. Despite the necessity of improved nutrition for these groups, some members do not fully meet their recommended daily micronutrient needs, a challenge exacerbated by different socioeconomic, cultural, and communal constraints resulting in malnutrition. Iron deficiency anaemia is a major concern among children and mothers, especially in pastoralist communities, due to poor nutrition and other related factors.
View Article and Find Full Text PDFWhole Brain MRI Assessment of Age and Sex-Related R2* Changes in the Human Fetal Brain.
Hum Brain Mapp
February 2025
Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, New York, USA.
Iron in the brain is essential to neurodevelopmental processes, as it supports neural functions, including processes of oxygen delivery, electron transport, and enzymatic activity. However, the development of brain iron before birth is scarcely understood. By estimating R2* (1/T2*) relaxometry from a sizable sample of fetal multiecho echo-planar imaging (EPI) scans, which is the standard sequence for functional magnetic resonance imaging (fMRI), across gestation, this study investigates age and sex-related changes in iron, across regions and tissue segments.
View Article and Find Full Text PDFPrevalence of vitamin D deficiency and its association with adverse obstetric outcomes among pregnant women in Uganda: a cross-sectional study.
BMJ Open
January 2025
Department of Obstetrics and Gynaecology, Uganda Martyrs University, Mother Kevin Postgraduate Medical School, Nsambya Campus, Kampala, Uganda.
Objective: There is a dearth of published data on the vitamin D status of the Ugandan population; the objective of the study was to determine the prevalence of vitamin D deficiency among pregnant women in Uganda and its associations with maternal characteristics and adverse foetal-maternal outcomes.
Study Design And Setting: We conducted a cross-sectional study on pregnant women admitted to a tertiary referral hospital in Kampala, Uganda for delivery during the study period from July to December 2023.
Participants: The study was conducted on 351 pregnant women aged ≥18 years who consented to participate in the study, who had a single intrauterine pregnancy and a gestational age greater than 26 weeks, and who delivered at St.
Changes in doxylamine-pyridoxine dispensation in Ontario following media attention: Time-series analysis.
Can Fam Physician
January 2025
Assistant Professor in the Leslie Dan Faculty of Pharmacy at the University of Toronto, Scientist at Women's College Hospital Institute for Health System Solutions and Virtual Care in Toronto, Investigator with the Ontario Drug Policy Research Network, and Adjunct Scientist at ICES.
Objective: To understand the possible association between media coverage and changes in the dispensation of doxylamine-pyridoxine in Canada.
Design: Cross-sectional time-series analysis using data from the IQVIA CompuScript database.
Setting: Ten Canadian provinces.
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