Spiny keratoderma of the palms and soles has been rarely reported. Debate exists regarding the proper nosologic classification of this disorder. We describe a patient and her mother with concurrent autosomal dominant polycystic kidney disease with liver cysts.

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http://dx.doi.org/10.1016/s0190-9622(96)90084-5DOI Listing

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A 14-year-old male with disseminated superficial porokeratosis and a family history of the same lesions on his maternal side presented with spiny keratoderma. Spiny keratoderma is a dermatosis characterized by multiple punctate keratotic neoformations on the palms and soles. It is considered a rare disease, with fewer than 84 cases reported in the world medical literature to date.

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Article Synopsis
  • * Histological analysis shows these lesions are made up of distinct columns of abnormal keratin on a thin outer skin layer, and sporadic cases may be linked to chronic illnesses or cancers.
  • * A case study describes an elderly man with liver cirrhosis and cancer who experienced a remission of skin lesions two months after a liver transplant, suggesting the condition may relate to his cancer diagnosis.
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  • - Spiny keratoderma is a rare skin condition characterized by small, spiny growths on the palms and soles, which can be inherited or acquired.
  • - The acquired form may be linked to other health issues but not necessarily to cancer, and it can be confused with similar skin conditions like arsenical keratosis.
  • - This article discusses three cases of acquired spiny keratoderma in patients with different systemic diseases, highlighting that none had underlying malignancies.
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