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Connexin 43 contributes to perioperative neurocognitive disorder by attenuating perineuronal net of hippocampus in aged mice.
Cell Mol Life Sci
January 2025
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anesthesiology and Perioperative MedicineSchool of Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, 1239 Sanmen Road, Hongkou District, Shanghai, 200434, China.
Background: Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms of PND are closely related to perineuronal nets (PNNs). PNNs, which are complexes of extracellular matrix primarily surrounding neurons in the hippocampus, play a critical role in neurocognitive function.
View Article and Find Full Text PDFFactors Associated With the Presence and Severity of Nutritional Impact Symptoms in Individuals With Head and Neck Cancer Before Treatment.
Int J Surg Oncol
January 2025
Federal University of Espírito Santo (UFES), Vitória, Espírito Santo, Brazil.
As head and neck cancer (HNC) affects regions directly related to the digestive tract, it is consistently associated with nutritional impact symptoms (NISs), which further reduce food intake and affect nutritional status. Early identification of patients with NIS can assist therapy. This is a cross-sectional study with HNC patients from a cancer reference hospital.
View Article and Find Full Text PDFOptimising episodic encoding within segmented virtual contexts.
Conscious Cogn
January 2025
School of Psychology and Neuroscience, University of St. Andrews. KY16 9JP, United Kingdom.
The encoding of episodic memories depends on segmentation; memory performance improves when segmentation is available and performance is impaired when segmentation is absent. Indeed, for episodic memories to be created, the encoding of information into long-term memory requires the experience of event boundaries (i.e.
View Article and Find Full Text PDFQuantity of spontaneous touches to body and surface in very preterm and healthy term infants.
Front Psychol
December 2024
Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Background: Spontaneous movements are a crucial part of early motor development. Healthy term infants may produce up to 200 spontaneous touches to their body and surface in 10 minutes with their hands. The existing literature shows differences in early motor development between very preterm (<32 weeks gestation) and healthy term infants.
View Article and Find Full Text PDFHow investment in children shape fertility choices of families: Evidence from Pakistan.
PLOS Glob Public Health
December 2024
Research and Development Solutions, Islamabad, Pakistan.
Fertility patterns are transitioning globally in that couples are choosing to have fewer children as they become more affluent, and parents are investing more time and resources in the lives of their children than they can receive back. This change is more established in developed countries and is now being recognized in developing countries. We explored this phenomenon and its implications for family planning in Pakistan, hypothesizing a quantity-quality transition underway.
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