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Trigeminal Nerve Melanotic Schwannoma in Carney Complex.
Indian J Radiol Imaging
September 2022
Department of Neurosurgery, Apollo Hospitals, Sheshadripuram, Bengaluru, Karnataka, India.
Melanotic schwannoma (MS) is a rare peripheral nerve sheath tumor commonly found in the thoracic paraspinal region. It is present in an intracranial location rarely, with 18 out of 105 MS cases described in the literature. Trigeminal nerve was involved in only six of these cases.
View Article and Find Full Text PDFDefining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer.
Int J Mol Sci
October 2021
Centre for Craniofacial and Regenerative Biology, King's College London, London SE1 9RT, UK.
Neuroblastoma is a common extracranial solid tumour of childhood, responsible for 15% of cancer-related deaths in children. Prognoses vary from spontaneous remission to aggressive disease with extensive metastases, where treatment is challenging. Tumours are thought to arise from sympathoadrenal progenitor cells, which derive from an embryonic cell population called neural crest cells that give rise to diverse cell types, such as facial bone and cartilage, pigmented cells, and neurons.
View Article and Find Full Text PDFL3 rootlet recurrent melanocytic schwannoma - case report and literature review.
Folia Med (Plovdiv)
June 2021
Military Medical Academy, Sofia, Bulgaria.
First described by Miller in 1932, melanocytic schwannoma (MS) (melanotic schwannoma, pigmented schwannoma) is a rare variation of peripheral nerve sheet tumours with ectodermal origin occurring predominantly in somatic, but also in the autonomic peripheral system with around two hundred cases in the literature. Predominantly benign tumours, MS are still imaging and pathological challenge and can be easily misdiagnosed with more aggressive peripheral nerve tumours.We report a case of melanocytic schwannoma on L3 sensory rootlet with systematic literature review of nearly 200 cases presented in intracranial, paraspinal region, thoracic, abdominal or pelvic cavities and skin.
View Article and Find Full Text PDFMelanotic Schwannoma, a Deceptive Misnomer for a Tumor With Relative Aggressive Behavior: A Series of 7 Cranial and Spinal Cases.
Int J Surg Pathol
December 2020
Tata Memorial Hospital and ACTREC, 29436Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
The authors present in this article a series of 7 intracranial/spinal cases of melanotic schwannomas that highlight the aggressive nature of these tumors. The series comprises 2 males and 5 females, age range 19 to 50 years, with spinal/paraspinal location in 4/7 (57%), and intracranial (along the trigeminal nerve) location in 3/7 (43%). There was no association with Carney's complex.
View Article and Find Full Text PDF8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review.
World Neurosurg
September 2019
Department of Orthopaedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:
Background: Primary melanocytic neoplasms in the central nervous system are rare lesions arising from leptomeningeal melanocytes. These lesions produce neural deficits that resemble those of a meningioma or a schwannoma radiologically.
Case Description: A tumor around the left S1 root with an extension into the left paraspinal compartment was identified in a 32-year-old female with persistent left leg pain for 6 months.
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