With the exception of lipoma, neoplasia of the gastrointestinal tract is rare in horses. Lymphosarcoma is the most common neoplasm of the hematopoietic system in horses. In horses with lymphosarcoma of the large colon, clinical signs may include intermittent signs of mild abdominal pain, weight loss, pyrexia, and pelvic flexure impaction caused by impingement of the colonic lumen by the mass. Peritoneal fluid analysis may be normal or have a high total protein concentration. If signs of metastasis are not evident, resection of the large colon affected by the mass may prolong survival.
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