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[Results of and prospects for methods of determination of the frequency of mutant cells for glycophorin A and T-cell receptor loci to estimate long-term genotoxic effect of ionizing radiation].
Radiats Biol Radioecol
April 2001
Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk, 249020 Russia.
The usage of two methods for assessment of somatic gene mutations for the purpose of biological dosimetry and estimation of consequences of irradiation at long time after the exposure has been discussed. The determination of cells bearing mutated glycophorin A (GPA) locus is a reliable method for biodosimetry at both short and long time after the acute irradiation according to our results and the data of other authors. For prolonged exposure, the GPA-method is less informative than in cases of acute irradiation.
View Article and Find Full Text PDFDetermination of somatic mutant frequencies at glycophorin A and T-cell receptor loci for biodosimetry of acute and prolonged irradiation.
Appl Radiat Isot
May 2000
Department of Radiation Biochemistry, Medical Radiological Research Center of RAMS, Obninsk, Russia.
Somatic mutant frequencies at glycophorin A (GPA) and T-cell receptor (TCR) loci were assessed. The dependence of the GPA mutant frequency on doses of acute and prolonged irradiation was shown. In the case of acute irradiation the GPA mutant frequency displayed a three-fold greater dose-related increase as compared to prolonged irradiation.
View Article and Find Full Text PDFDetermination of somatic mutant frequencies at glycophorin A and T-cell receptor loci for biodosimetry of prolonged irradiation.
Int J Radiat Biol
June 1998
Department of Radiation Biochemistry, Medical Radiological Research Center of Russian Academy of Medical Sciences, Obninsk.
Purpose: To determine the variant frequencies (VF) at glycophorin A (GPA) and T-cell receptor (TCR) loci in persons exposed to prolonged ionizing radiation at different doses and to assess the significance of the GPA and TCR assays for biodosimetry of prolonged irradiation.
Materials And Methods: The VF values were determined by means of flow cytometry in 120 persons exposed between 1968-1996. Most exposures were in Chernobyl clean-up workers in 1986-1987.
[The estimation of the level of mutations at the glycophorin A locus in subjects exposed to the chronic action of ionizing radiation].
Radiats Biol Radioecol
August 1998
State Research Center of Russia, Institute of Biophysics, Moscow.
11 persons, who had been irradiated chronically at low dose rate under occupational conditions in 1950s in doses 220-581 cGy according data of individual film dosimeters, and 5 control persons were examined regarding the level of glycophorin A (GPA) mutation type NO and NN in blood erythrocytes. Significantly higher level of GPA mutations type NO was registered in average in the group of exposed persons (23.2 +/- 4.
View Article and Find Full Text PDFBiodosimetry of Chernobyl cleanup workers from Estonia and Latvia using the glycophorin A in vivo somatic cell mutation assay.
Radiat Res
February 1997
Center for Environmental and Occupational Health and Toxicology, University of Pittsburgh, and Molecular Carcinogenesis Program, University of Pittsburgh Cancer Institute, Pennsylvania 15238, USA.
The reactor accident at Chernobyl in 1986 necessitated a massive environmental cleanup that involved over 600,000 workers from all 15 Republics of the former Soviet Union. To determine whether the whole-body radiation received by workers in the course of these decontamination activities resulted in a detectable biological response, over 1,500 blood samples were obtained from cleanup workers sent from two Baltic countries, Estonia and Latvia. Here we report the results of studies of biodosimetry using the glycophorin A (GPA) locus in vivo somatic cell mutation assay applied to 734 blood samples from these workers, to 51 control samples from unexposed Baltic populations and to 94 samples from historical U.
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