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Chiral Oxazoline-Triazole-Benzothiazole Molecular Triads: Photoactive Sensors for Enantioselective Carbohydrate Recognition in Solution.
JACS Au
January 2025
Instituto de Química, Universidade Federal do Rio Grande do Sul-UFRGS, Av. Bento Gonçalves 9500, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
Understanding the mechanism of drug action in biological systems is facilitated by the interactions between small molecules and target chiral biomolecules. In this context, focusing on the enantiomeric recognition of carbohydrates in solution through steady-state fluorescence emission spectroscopy is noteworthy. To this end, we have developed a third generation of chiral optical sensors for carbohydrates, distinct from all of those previously presented, which interact with carbohydrates to form non-covalent probe-analyte interactions.
View Article and Find Full Text PDFA critical review of heat pump adoption in empirical and modeling literature.
iScience
January 2025
Colorado State University, Fort Collins, CO 80523, USA.
Household electrification is an important pillar of decarbonization in the US and requires the rapid adoption of electric heat pumps. Household energy models that project adoption rates do not represent these decisions well. To what extent are they limited by fundamental knowledge gaps, or is there scope to incorporate insights from the social science literature? We review the energy modeling and social science literature on heating equipment adoption to synthesize our understanding of adoption decisions, to identify best practices on representing decision-making behavior among energy models, and to suggest model improvements.
View Article and Find Full Text PDFIn this paper, we propose simultaneous and sequential hybrid brain-computer interfaces (hBCIs) that incorporate electroencephalography (EEG) and electromyography (EMG) signals to classify drivers' hard braking, soft braking, and normal driving intentions to better assist driving for the first time. The simultaneous hBCIs adopt a feature-level fusion strategy (hBCI-FL) and classifier-level fusion strategies (hBCIs-CL). The sequential hBCIs include the hBCI-SE1, where EEG signals are prioritized to detect hard braking, and hBCI-SE2, where EMG signals are prioritized to detect hard braking.
View Article and Find Full Text PDFBackgrounds: Breech presentation, family history, and physical examination are the most recognized risk factors for DDH, which form the basis of selective screening. However, this approach can lead to late diagnosis, invasive treatments, and complications. This study analyzes the effectiveness of selective screening and identifies additional factors related to DDH.
View Article and Find Full Text PDFDevelopment of a clinical-radiological nomogram for predicting severe postoperative peritumoral brain edema following intracranial meningioma resection.
Front Neurol
January 2025
Department of Neurosurgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Objective: The goal of this study was to develop a nomogram that integrates clinical data to predict the likelihood of severe postoperative peritumoral brain edema (PTBE) following the surgical removal of intracranial meningioma.
Method: We included 152 patients diagnosed with meningioma who were admitted to the Department of Neurosurgery at the Affiliated People's Hospital of Jiangsu University between January 2016 and March 2023. Clinical characteristics were collected from the hospital's medical record system.
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