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SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1.
J Cardiothorac Surg
January 2025
Department of Respiratory and Critical Care Medicine, Datian County General Hospital, 180 Xueshan North Road, Datian County, 366100, China.
Background: Lung adenocarcinoma is the most common form of lung cancer and one of the most life-threatening malignant tumors. Ferroptosis is an iron-dependent regulatory cell death pathway that is crucial for tumor growth. SNX30 is a key regulatory factor in cardiac development; however, its regulatory mechanism and role in inducing ferroptosis in lung adenocarcinoma remain unclear.
View Article and Find Full Text PDFIdentifying Bacteria Responsible for Non-Sulphate-Based Hydrogen Sulphide Production in Aquaculture.
Environ Microbiol
January 2025
DTU Aqua, Section for Aquaculture, Technical University of Denmark, Hirtshals, Denmark.
The unintended microbiological production of hydrogen sulphide (HS) poses a significant challenge in engineered systems, including sewage treatment plants, landfills and aquaculture systems. Although sulphur-rich amino acids and other substrates conducive to non-sulphate-based HS production are frequently present, the capacity and potential of various microorganisms to perform sulphate-free HS production remain unclear. In this study, we identify the identity, activity and genomic characteristics of bacteria that degrade cysteine to produce HS in anaerobic enrichment bioreactors seeded with material from aquaculture systems.
View Article and Find Full Text PDFPorous Nanoframe Based Plasmonic Structure With High-Density Hotspots for the Quantitative Detection of Gaseous Benzaldehyde.
Small
January 2025
Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission, Key Laboratory of Photosensitive Materials & Devices of Liaoning Province, School of Physics and Materials Engineering, Dalian Minzu University, Dalian, 116600, China.
Owing to its high sensitivity, surface-enhanced Raman scattering (SERS) has immense potential for the identification of lung cancer from the variation in volatile biomarkers in the exhaled gas. However, two prevailing factors limit the application of SERS: 1) the adsorption of target molecules into SERS hotspots and 2) the detection specificity in multiple interference environments. To improve the density of the SERS hotspots, 3D Au@Ag-Au particles are prepared in a porous nanoframes (PPFs) based plasmonic structure, which facilitated a richer local electromagnetic field distribution among the Au nanocubic (NC) cores, Au-Ag porous nanoframes, and Au nanoparticles, thereby promoting the adsorption probability of gaseous aldehydes into the hotspots.
View Article and Find Full Text PDFJapanese Leaf Burdock Extract Inhibits Adipocyte Differentiation in 3T3-L1 Cells.
Plant Foods Hum Nutr
January 2025
Department of Food Science and Nutrition, School of Food Science and Nutrition, Mukogawa Women's University, 6-46, Ikebiraki-Cho, Nishinomiya, Hyogo, 663-8558, Japan.
Burdock, Arctium lappa Linn. (Asteraceae), is cultivated in East Asian for its edible roots, and its seeds are used in a herbal medicine. Burdock seeds and roots exhibit anti-adipogenic activity.
View Article and Find Full Text PDFCell-Active, Arginine-Targeting Irreversible Covalent Inhibitors for Non-Kinases and Kinases.
Angew Chem Int Ed Engl
January 2025
Sun Yat-sen University - Shenzhen Campus, School of Pharmaceutical Sciences (Shenzhen), CHINA.
Targeted covalent inhibitors (TCIs) play an essential role in the fields of kinase research and drug discovery. Most existing TCIs are however cysteine- or lysine-reactive, thus severely limiting their potential applications. New types of TCIs capable of covalently targeting other nucleophilic amino acids that are readily available in proteins are urgently needed.
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