AI Article Synopsis
- The study examined how sodium saccharin and linoleic acid affect Her2/neu and p53 mRNA levels in a non-cancerous breast cell line (HBL-100), comparing these effects to the known tumor promoter TPA.
- Small but notable increases in Her2/neu mRNA (46-67%) were observed with TPA and sodium saccharin after NMU treatment.
- The findings indicate that sodium saccharin may have a role in regulating Her2/neu transcription in breast cells, suggesting broader implications beyond just urinary bladder effects.
Article Abstract
The effects of two food-related chemicals (sodium saccharin and linoleic acid) on the levels of Her2/neu and p53 mRNA in a non-cancerous human breast epithelial cell line (HBL-100) were tested in comparison with the effects of the known tumor promoter phorbol 12-myristate 13-acetate (TPA). Treatments were made both with and without prior treatment with two well-known tumor initiators, N-nitroso-N-methylurea (NMU) or 7,12-dimethylbenz[a]anthracene (DMBA). The effects in general were small, the greatest being increases of 46-67% in Her2/neu mRNA levels in response to treatments with TPA or sodium saccharin following NMU treatments. These results demonstrate that sodium saccharin following NMU treatments might be involved in transcriptional regulation of Her2/neu in HBL-100 cells and suggest that its effects may not be limited to urinary bladder.
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| http://dx.doi.org/10.1016/0304-3835(96)04170-5 | DOI Listing |
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