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Two-year randomized controlled trial of circumferential versus segmental ab externo angle surgery in patients with primary open angle glaucoma.
Jpn J Ophthalmol
January 2025
Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Purpose: To compare the surgical outcomes of visco-circumferential-suture-trabeculotomy (VCST) and rigid probe segmental viscotrabeculotomy (VT) in primary open-angle glaucoma (POAG).
Study Design: A prospective randomized controlled study.
Patients And Methods: Patients presenting with POAG and operated upon in Mansoura Ophthalmic Center in Mansoura, Egypt between February 2017 and September 2021 were enrolled.
The role of RGC degeneration in the pathogenesis of glaucoma.
Int J Biol Sci
January 2025
Department of Ophthalmology, The Second Hospital of Jilin University, Jilin University, Changchun 130000, Jilin, China.
Glaucoma is a neurodegenerative disorder marked by the loss of retinal ganglion cells (RGCs) and axonal degeneration, resulting in irreversible vision impairment. While intraocular pressure (IOP) is presently acknowledged as the sole modifiable risk factor, the sensitivity of RGCs to IOP varies among individuals. Consequently, progressive vision loss may ensue even when IOP is effectively managed.
View Article and Find Full Text PDFA case of uveoscleral mucosa-associated lymphoid tissue lymphoma with secondary angle-closure glaucoma.
BMC Ophthalmol
December 2024
Department of Ophthalmology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Background/aim: Mucosa-associated lymphoid tissue (MALT) lymphomas occur in not only the ocular adnexa, but rarely in the sclera or uvea. Histopathological confirmation contributes to a better understanding of the pathogenesis and treatment. We report a case of uveoscleral MALT lymphoma with angle-closure glaucoma.
View Article and Find Full Text PDFUrrets-Zavalia syndrome (UZS) stands out as a rare yet clinically consequential complication associated with ophthalmic surgery, marked by the emergence of a fixed and dilated pupil. While it was originally described post-penetrating keratoplasty (PKP) in patients with keratoconus and its prevalence is notably higher following PKP, instances of UZS have been documented in the context of other procedures, including intraocular lens implantation, Descemet-stripping endothelial keratoplasty and Descemet membrane endothelial keratoplasty (DMEK). We report a unique case of bilateral UZS after uneventful DMEK surgeries, highlighting a rare but potential complication after DMEK.
View Article and Find Full Text PDFRetinal cytoarchitecture is preserved in an organotypic perfused human and porcine eye model.
Acta Neuropathol Commun
November 2024
Donald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Article Synopsis
- - The study addresses the difficulties in researching human retinal pathobiology due to accessibility issues and limited samples, highlighting the need for new models that preserve retinal structure and function.
- - An ex vivo organotypic model was developed to evaluate how normal intraocular pressure (IOP) and fluid flow affect retinal tissue, showing that these conditions help maintain cytoarchitecture and cell survival for up to 24 hours.
- - Results indicated that retinas under physiological perfusion had minimal cell death and preserved metabolism, unlike control eyes without perfusion, demonstrating the importance of IOP and fluid flow for retinal health and providing a new model for further research.
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