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The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.
Netw Neurosci
December 2024
Science for Life Laboratory, Department of Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behavior, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons, and the remaining 5% are GABAergic and cholinergic interneurons.
View Article and Find Full Text PDFAdaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.
Cell Mol Life Sci
December 2024
Univ Angers, INSERM, CNRS, MITOVASC, Équipe CARME, SFR ICAT, F-49000 Angers, France.
Chronic elevated blood pressure impinges on the functioning of multiple organs and therefore harms body homeostasis. Elucidating the protective mechanisms whereby the organism copes with sustained or repetitive blood pressure rises is therefore a topical challenge. Here we address this issue in the adrenal medulla, the master neuroendocrine tissue involved in the secretion of catecholamines, influential hormones in blood pressure regulation.
View Article and Find Full Text PDFSynaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease.
Neurobiol Dis
December 2024
Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address:
Background: Altered balance between striatal direct and indirect pathways contributes to early motor, cognitive and psychiatric symptoms in Huntington disease (HD). While degeneration of striatal D2-type dopamine receptor (D2)-expressing indirect pathway medium spiny neurons (iMSNs) occurs prior to that of D1-type dopamine receptor (D1)-expressing direct pathway neurons, altered corticostriatal synaptic function precedes degeneration. D2-mediated signaling on iMSNs reduces their excitability and promotes endocannabinoid (eCB) synthesis, suppressing glutamate release from cortical afferents.
View Article and Find Full Text PDFTRPM7 contributes to pyroptosis and its involvement in status epilepticus.
J Neuroinflammation
December 2024
Department of Pharmacy, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China.
Article Synopsis
- The study investigates pyroptosis, a form of programmed cell death, in the context of status epilepticus (SE), a condition marked by prolonged seizures, and how it relates to neurodegeneration.
- Researchers induced SE in mice using pilocarpine and found increased levels of inflammatory markers and TRPM7 expression, identifying TRPM7 as a key player in neuronal damage and hyperexcitability.
- The findings suggest that targeting TRPM7 and NLRP3 could be a potential treatment strategy for SE, as inhibiting these pathways alleviated neuronal hyperexcitability and pyroptosis.
Facile green preparation of highly fluorescent nitrogen-doped carbon dots from bagasse for sensitive methyl parathion detection.
Food Chem
February 2025
Guangxi Key Laboratory of Green Processing of Sugar Resources, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, PR China.
In this work, a high sensitivity fluorescence sensor system utilizing nitrogen-doped carbon dots (N-CDs) from bagasse was studied. A method was developed to examine methyl parathion (MP) via alkali hydrolysis. N-CDs were prepared via hydrothermal method from biomass bagasse.
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