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Detecting CYP2C19 genes through an integrated CRISPR/Cas13a-assisted system.
Anal Methods
January 2025
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
CYP2C19 gene single nucleotide polymorphisms (SNPs) should be considered in the clinical use of clopidogrel as they have important guiding value for predicting the risk of bleeding and thrombosis after clopidogrel treatment. The CRISPR/Cas system is increasingly used for SNP detection owing to its single-nucleotide mismatch specificity. Simultaneous detection of multiple SNPs for rapid identification of the CYP2C19 genotype is important, but there is no method to detect a wide variety of CYP2C19 SNPs.
View Article and Find Full Text PDFAdvances in nanoparticle-based radiotherapy for cancer treatment.
iScience
January 2025
Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Radiotherapy has long been recognized as an effective conventional approach in both clinical and scientific research, primarily through mechanisms involving DNA destruction or the generation of reactive oxygen species to target tumors. However, significant challenges persist, including the unavoidable damage to normal tissues and the development of radiation resistance. As a result, nanotechnology-based radiotherapy has garnered considerable attention for its potential to enhance precision in irradiation, improve radiosensitization, and achieve therapeutic advancements.
View Article and Find Full Text PDFRecent advances in innovative biomaterials for promoting bladder regeneration: processing and functionalization.
Front Bioeng Biotechnol
January 2025
The Second Hospital of Jilin University, Changchun, China.
The bladder is a dynamic organ located in the lower urinary tract, responsible for complex and important physiological activities in the human body, including collecting and storing urine. Severe diseases or bladder injuries often lead to tissue destruction and loss of normal function, requiring surgical intervention and reconstruction. The rapid development of innovative biomaterials has brought revolutionary opportunities for modern urology to overcome the limitations of tissue transplantation.
View Article and Find Full Text PDFIntegrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms.
Biomater Sci
January 2025
School of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Thrombosis, a major cause of morbidity and mortality worldwide, presents a complex challenge in cardiovascular medicine due to the intricacy of clotting mechanisms in living organisms. Traditional research approaches, including clinical studies and animal models, often yield conflicting results due to the inability to control variables in these complex systems, highlighting the need for more precise investigative tools. This review explores the evolution of thrombosis models, from conventional polydimethylsiloxane (PDMS)-based microfluidic devices to advanced hydrogel-based systems and cutting-edge 3D bioprinted vascular constructs.
View Article and Find Full Text PDFScalable, Flexible, and UV-Resistant Bacterial Cellulose Composite Film for Daytime Radiative Cooling.
ACS Appl Mater Interfaces
January 2025
School of Chemistry and Materials Science, Jiangsu Key Laboratory of New Energy Devices & Interface Science, Nanjing University of Information Science & Technology, Ning-Liu Road 219, Nanjing 210026, China.
Radiative cooling, a passive cooling technology, functions by reflecting the majority of solar radiation (within the solar spectrum of 0.3-2.5 μm) and emitting thermal radiation (within the atmospheric windows of 8-13 μm and 16-20 μm).
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